摘要
以光镜、电镜、胶体金探针免疫电镜、组化和免疫组化等方法，观察１６例脾原发性非何杰金淋巴瘤（ＮＨＬ），发现其镜下分布有三种基本类型，即结节型、弥漫型和过渡型。发现属低度恶性的不同组织学类型ＮＨＬ在红髓和白髓有特殊的浸润方式：结节型小裂细胞性，其结节分布于整个脾脏的红髓，大小及分布较一致，未见侵犯红髓，但有独特的侵犯中央动豚周围Ｔ细胞淋巴鞘的形态，且可能与淋巴细胞循环和“归家”机制有关；过渡型小无裂细胞性，主要呈结节状，但红髓可见小片弥漫的瘤细胞浸润，并与结节有移行改变；过渡型Ｂ混合细胞性，结节较少，部分红髓破坏，代之以弥漫分布的瘤细胞。而弥漫型则主要见于恶性程度较高的组织细胞性和大裂细胞性等。此外，还讨论了脾原发性ＮＨＬ的鉴别诊断、诊断标准、大体分型和临床特点等问题。
Sixteen cases of the primary non-Hodgkin's lymphoma (NHL) of the spleen wereobserved with light microscope,electron microscope(EM),immuno-EM,histochemistryand immunohistochemistry. Three basic types of NHL were noted:nodular,diffused andtransitional.Low malignant NHL with different histologic type infitrated the red pulp andwhite pulp in special way. For the nodular small cleaved cytic, the nodes were seen to distribute to almost all the red pulp without invating the red pulp,but invated the periarteriolarT-lymphocyte sheath,which may be related to the lymphocyte cycle and resettlement.In thetransitional small cleaved cytic,besides the nodular shape,a small groups of diffusing tumorcells were located in the red pulp,In the transitional B-mixed,the nodes are fewer and someof the red pulp were destroyed,replaced of the diffusing cells. The former was simple nodular and the later two were the transition from the nodular to the diffused,while the diffusedwas mainly found in the histocytic type and the large cleaved type with higher malignancy.Additionally,the differential diagnosis and the clinical character were also discussed.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1995年第2期95-98,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
脾脏肿瘤
非何杰金淋巴瘤
电镜
病理学
免疫组化
spleen tumor
lymphoma
immunoelectron microscope
pathology
immunohistochemistry
