摘要
在香烟烟油(0.26～2.6 mg/ml)作用下,以酵母多糖诱发和鲁米诺或光泽精增强的二种兔全血化学发光强度都呈现浓度相关的抑制效应。Evans蓝排斥试验表明,烟油没有显著的细胞毒性,说明上述抑制现象是粒细胞氧合作用活性,免疫功能受到烟油抑制所致。提示吸烟者粒细胞吞噬功能降低,其结果不仅影响抗感染、抗炎症作用,而且与肿瘤的发生也有一定关系。此外,还分析了烟油抑制效应的可能作用机理。
Both luminol- and lucigenin-dependent rabbit whole blood chemilumi-nescence showed a concentration-dependent inhibition response to cigarette-smoke tar of 0.26 to 2.6mg/ml. Tar showed no cytotoxicity to granulocytes by Evans blue exclusion. It is suggested that oxygenation activity of granulocytes in smoker's blood could be depressed by tar, resulting in harmful effects on the host defense mechanism with increase of susceptibility to infection and incidence of tumorigenicity.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1989年第1期25-29,共5页
Acta Academiae Medicinae Sinicae
关键词
烟油
粒细胞
氧合作用
化学发光
smoke tar chemiluminescence granulocyte oxygenation
