摘要
检测配对设计的５４例多发性脑梗塞痴呆（ＭＣＩＤ）患者和５４例健康老年人血浆维生素Ｃ（Ｐ－ＶＣ）、血浆维生素Ｅ（Ｐ－ＶＥ）含量及血浆和红细胞超氧化物歧化酶（Ｐ－ＳＯＤ、Ｅ－ＳＯＤ）活性、血浆和红细胞过氧化脂质（Ｐ－ＬＰＯ、Ｅ－ＬＰＯ）的含量。结果表明：与对照组比较，患者组的平均Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－ＳＯＤ和Ｅ－ＳＯＤ值均显著降低（Ｐ＜０．００１），平均Ｐ－ＬＰＯ和Ｅ－ＬＰＯ含量均显著升高（Ｐ＜０．００１）；５４例患者的Ｐ－ＶＣ、Ｐ－ＶＥ含量均与Ｐ－ＳＯＤ、Ｅ－ＳＯＤ值呈直线正相关，均与Ｐ－ＬＰＯ、Ｅ－ＬＰＯ含量呈直线负相关；患者病程与Ｐ－ＶＣ、Ｐ－ＶＥ、Ｅ－ＳＯＤ值呈直线负相关，与Ｐ－ＬＰＯ、Ｅ－ＬＰＯ含量呈直线正相关；患者智能受损程度与Ｐ－ＶＣ、Ｐ－ＶＥ含量呈直线负相关，与Ｐ－ＬＰＯ和Ｅ－ＬＰＯ含量呈直线正相关；提示ＭＣＩＤ患者体内的抗氧化剂含量和抗氧化酶活性显著降低及脂质过氧化反应明显加剧。
The results of measuring plasma vitamin C (P-VC), plasma vitamin E (P-VE) contents , plasma superoxide dismutase activity(P-SODA), erythrocyte superoxide dismutase activity(E-SODA). plasma lipoperoxides(P-LPO) and erythrocyte lipoperoxides (E-LPO) contents of 54 multiple cerebral infarction dementia patients and 54 health aged subjects showed that the average P-VC , P-VE , P-SODA, E-SODA values of the patient group were all significantly lower than those of the control group (P<0. 001). The average P-LPO,E-LPO values of the patient group were all significantly higher than those of the control group (P<0. 001 ).P-VC and P-VE, P-VC and P-SODA, E-SODA, P-VE and P-SODA, E-SODA were all presented positive linear correlation ship. P-VC and P-LPO , E-LPO , P-VE and P-LPO, E-LPO were all in negative linear correlation. The clinical courses of the patient and P-VE, P-VE, E-SODA were all in negative linear correlatioin, but the course and P-LPO, E-LPO were all in positive linear correlation. The degee of intelligence damage and P-VC, P-VE were in all negative lineas correlation. but degree of intelligence damage and PLPO, E-LPO were all in positive linear correlation.
出处
《中国老年学杂志》
CAS
CSCD
1995年第5期266-268,共3页
Chinese Journal of Gerontology
关键词
多发性
脑梗塞痴呆
维生素C
超氧化物歧化酶
Multiple cerebral infarction dementia VC VE Superoxide dismutase Lipoperoxides
