摘要
将天然海珊瑚碳酸钙经过“热液交换反应”制成珊瑚羟基磷灰石人工骨。用８０Ｒ新西兰兔为实验动物，组织学结果显示该人工骨有良好的的生物相容性和传导成骨作用。与自体红骨髓复合具有明显的成骨诱导活性。生物力学测试，植入术后１６周尺骨标本的最大扭矩分别为：人工骨组５２．０４Ｎ·ｃｍ，自体移植骨组３４．８８Ｖ·ｃｍ，正常骨组６１．１（）Ｎ·ｃｍ。证明珊瑚羟基磷灰石人工骨与宿主骨结合能力强，愈合后强度优异，适合于长骨干缺报的修复。
he bone graft substitute of coralline
hydroxyapatic(CHA)was made from coral skeletalcarbonate through
hydrothermal exchange at specified condition.A porous structure of
200 μm inpore diameter,and 53% porosity was observed by SEM.
Animal experiment with 80 New Zealandwhite rabbits showed that CHA
pocessed good biocompatibility and osteoconductability.
Biome-chanical test of bone specimens in 16 weeks after implantation
showed that the maximum torquesare respectivly 52.4N. cm, 34.9 N. cm
and 61.1 N. cm in the artificial bone group,the autograftgroup and
the control group. CHA artificial bone has a good bonding strength
with host bonesand is suitable for the repair of segmental diaphyseal
defect.
出处
《中国临床解剖学杂志》
CSCD
北大核心
1995年第4期289-293,共5页
Chinese Journal of Clinical Anatomy
关键词
人工骨
珊瑚羟基磷灰石
形态学
骨缺损
bone graft substitute
coralline
hydroxyapatite
biomechanics
morphology
