摘要
本文报告了中药枸杞子（Ｌｙｃｉｕｍｂａｒｂａｒｕｍ，ＬＢ）对Ｔ、Ｂ淋巴细胞增殖和Ｔ细胞亚群的调节作用。实验结果指出，枸杞对未经活化的淋巴细胞没有诱导增殖的作用；对于分别经ＰＨＡ和ＰＭＡ活化的淋巴细胞增殖有显著的促进作用（Ｐ＜０．０５），这表明枸杞对活化的Ｔ、Ｂ淋巴细胞的增殖有促进作用。选择最大促进效应浓度的ＬＢ对ＰＨＡ活化的Ｔ淋巴细胞亚群的变化进行双标记检测，结果指出，和ＰＨＡ活化后的情况相比，ＬＢ的作用导致ＣＤ４￣－ＣＤ８￣＋和ＣＤ４￣＋ＣＤ８￣＋细胞比例明显下降，同时使ＣＤ４￣＋ＣＤ８￣－细胞比例显著增加，表现出免疫促进作用。同时实验结果还显示，枸杞的免疫调节作用和剂量有关。
he regulation effect of
chinese medicine Lycium barbarum (LB) on lympho-proliferationand T
lymphocyte subpopulations has been studied. The LB sample was
perparated using bio-chemical methods. In the absence of mitogin, LB
could not induce inactivated lymphocyte toproliferation; but PHA- and
PMA-activited lymphocyte is obviously increased in
proliferationespecially after treatment with LB in the simular
concentration (P<0. 05). T lymphocyte sub-sets was assessed after
treatment with PHA and LB in the optimal concentration, meanwhiletake
fresh and PHA activated lymphocyte as control. It is observed that LB
treatment causeddecreasing of CD4￣-CD8￣+ and CD4￣+CD8￣+ cell
group , while CD4￣+CD8￣- cell group increased ob-viously. These
results has suggested that the chinese medicine LB has the
immuno-improving ef-fect ,improving activited T and B lymphocyte
proliferation , and increasing the CD4￣+CD8￣- cellgroup (T help
cell) , reducing the CD4￣-CD8￣+ ,CD4￣+CD8￣+ cell groups (which
are thought to beimmune suppression groups ) .
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1995年第3期163-166,共4页
Chinese Journal of Immunology
关键词
枸杞
T淋巴细胞
B淋巴细胞
T淋巴细胞亚群
Chinese
medicine lycium barbarum Lymphocyte ProliferationT lymphocyte
subpopulation
