摘要
单体皂甙Ｒｂ３自西洋参茎叶皂甙中提取。Ｒｂ３３０ｍｇ·ｋｇ－１可使麻醉大鼠在体心脏的ＭＡＰ，±ｄＰ／ｄｔｍａｘ和ＬＶＳＰ减少。用斑片钳的连细胞电压钳法证明．Ｒｂ３３００ｍｇ·Ｌ－１使Ｌ、Ｂ、Ｔ型钙通道的开放时间缩短、开放概率减少，其作用与异搏定３７．５ｍｇ·Ｌ－１相似，与ＢａｙＫ８６１１５μｍｏｌ·Ｌ－１作用相反。确切地证明Ｒｂ３对钙通道有阻滞作用。
Saponin monomer Rb3 was extracted from the stems and leaves of Panaxquinquefolium.Rb3 30 mg· kg-1 decreased the MAP.±dP/dtmax and LVSP of anaesthetic rat hearts in vivo. Using the cell attached configration of the patch clamp technique,it was demonstrated that Rb3 300 mg· L-1 decreased the open time and the open-state probabillity of L. Band T type calcium channels. The effect was similar to that of verapamil 37.5 mg·L-1 and opposite to that of Bay K8644 5 μmol· L-1. Theresults conclusively prove that Rb3 has blockade effect on calcium chanls.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1995年第1期39-43,共5页
Chinese Pharmacological Bulletin
关键词
西洋参
皂甙
钙通道
血流动力学
panax quinquefolium
saponin
calcium channel
patch clamp
hemodynamics
