摘要
研究萱草活性成份黄酮干对糖尿病大鼠血糖、血脂、血浆脂蛋白脂质过氧化的影响.方法取20只雄性大鼠(Ⅱ型糖尿病模型),随机分为2组:对照组喂普通饲料,实验组喂添加10 g/kg黄酮干的饲料20周,观察血液生化指标的变化.血液生化指标采用试剂盒测定,血浆脂蛋白采用序列超速离心分离法分离.结果喂饲萱草活性成份黄酮干的糖尿病大鼠血糖为(10.3±0.7)mmol/L,动脉粥样硬化指数为0.38±0.12,血浆过氧化脂质水平为(13.7±0.2)mmol/L;丙二醛(MDA)水平为(7.45±1.26)(nmol/mgHb),超氧化歧化酶(SOD)活性为(153.47±37.91)(活力单位/m l);未喂饲黄酮干的对照组糖尿病大鼠上述指标分别为(13.5±1.6)mmol/L、0.54±0.24和(20.1±2.8)mmol/L,(13.01±0.74)(nmol/mgHb),和(210.98±40.11)(活力单位/m l),差异有显著性.结论萱草活性成份黄酮干具有明显的降低血糖、改善动脉粥样硬化指数、抑制脂质过氧化的作用.表4,参5.
Objective To study the influence of flavone of Hemerocallis fulva L.extract containing on blood glucose,blood lipids,plasma lipid peroxide and platelet aggregation activity in diabetic rats.Methods Diabetic rats were fed with fodder containing 10g/kg of flavone for 20 weeks.Their index of biochemistry were separated by sequential ultracentrifugation.Results Twenty weeks after experiment,level of blood glucose,atherosclerotic index and plasma level of lipid perocide were(10.3±0.7)mmol/L,0.38±0.12,(13.7±0.2)mmol/L,(7.45±1.26)(nmol/mgHb),(153.47±37.91)(activite unit/ml),respectively in diabetic rats fed with flavone,significantly lower than those in control rats not fed with it,(13.5±1.6)mmol/L、0.54±0.24 and(20.1±2.8)mmol/L,(13.01±0.74)(nmol/mgHb),and(210.98±40.11)(activite unit/ml),respectively.Changes in all these indices were significantly different between the two groups.Conclusion flavone could significantly decrease blood glucose,impuoeve atherosclerotic index,and inhibit lipid perooxidation and platelet aggregation in diabetic rats,which might be useful in prevention and control of diabetes mellitus and diabetes-associated atherosclerosis.4tabs.,5refs.
出处
《湖南环境生物职业技术学院学报》
CAS
2010年第4期26-28,共3页
JOurnal of Hunan Environment Biological Polytechnic
基金
衡阳市科技局基金项目(编号:2007KS16)
