摘要
目的:探讨同型半胱氨酸(Hcy)及其代谢相关因子(叶酸、维生素B12)和血脂与急性冠状动脉综合征(ACS)之间的关系。方法:110例ACS患者(ACS组)及110例性别和年龄相匹配的非心脑疾病者(对照组),应用高效液相色谱荧光分析法测定血浆Hcy浓度,同时测定叶酸、维生素B12浓度及血脂水平,分析血浆Hcy与ACS有无相关性,并进一步分析Hcy与叶酸和维生素B12之间的关系。结果:①ACS组血浆Hcy浓度[(16.75±11.97)mmol/L]高于对照组[(13.15±5.65)mmol/L],(P<0.05)。②血浆Hcy浓度和血浆叶酸、维生素B12浓度呈明显的非线性负相关。③ACS组血脂与Hcy水平无明显相关。结论:高Hcy血症是ACS的一个新的危险因素,叶酸、维生素B12是影响ACS患者血浆Hcy水平的主要因素。
Objective： Hyperhomocysteinemia is an independentent risk factor of cardiovascular disease. However,there were no largescale deta about the influencing factors on plasma homocysteine （Hey） level in chinese documented. This study was aimed to investigate the plasma level and its affecting factors in Chinese patients with acute coronary syndrome（ACS）. Method：The 110 cases of ACS and 110 gender- and age-matched control subjects were enrolled and plasma Hey was determined by HPLC and their levels of plasma, lipid, folate,VitB12 were also determined by photochemical method. Result： ①Patients with ACS had significantly increased Plasma Hey level compared with control [（16.75±11.97）mmol/l vs （13.15±5.65）mmol/l, P 〈0. 05].② Plasma Hey levels had significant non-linear inverse relation with folate and VitB12 levels ③Plasma Hey concentrations were not correlated with lipid levels in patients with ACS. Conclusion： Hyperhomocysteinemia is a new risk factor to ACS and folate,Vitamin B12 were main influential factors to plasma homocysteine in ACS.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2005年第8期457-459,共3页
Journal of Clinical Cardiology
