摘要
目的探讨乙型肝炎病毒(HBV)感染与原发性肝癌(PHC)之间的关系和其病理特征。方法:经病理证实的105例PHC患者,检测了解其HBV感染史和感染模式,并分析肝组织的病理学变化,以探讨乙型肝炎病毒感染与原发性肝癌(PHC)之间的关系。结果:105例PHC患者中HBV感染102例,感染率达97.1%,以HBsAg、抗-HBe和抗-HBc的阳性率最高(53.3%),而HBsAg(+)、HBeAg(+)、抗-HBc阳性率次之(为23.8%).肝组织病理学特征:肝细胞癌(HCC)占94.3%(99/105),结节型、巨块型、小肝癌分别占60.9%、30.5%、和8.6%。多分布在肝右叶(占63.8%),85%合并有肝硬化。结论:HBV感染与原发性肝癌的发生关系密切,是PHC的主要病原学因素。PHC以肝细胞癌、低分化为主,主要分布在肝右叶、以结节型为主。
Objective To investigate the relationship between infection of hepatitis B Virus （HBV） and the occurrance of primary hepatic carcinoma（PHC） and its pathologic features. Methods One hundred and five patients with PHC were diagnosed by histopathologic examination . The history of HBV infection and its infective patterns were obtained and by analysis histopathologic changes. Results The markers of HBV were positive in 102 （97.1%） out of 105 cases. The positive rate of HBsAg anti-HBe and anti-HBc was the highest among the five markers of HBV （53. 3%）. The positive rate of HBsAg and HBeAg and anti-HBc was 23. 8%. Histopathologic features were as following： HCC accounted for 94.3 % ,and.nodular type , macro-type anti small hepatic carcinomas accounted for 60.9% 30.5% and 8.6% respectively. The distributions PHC were mainly in right lobe of liver（63.8%）. Conclusion There was a close relationship between the infection and the occurance of HBV and PHC . HBV infection is the main etiology factor for PHC.
出处
《江西医学院学报》
2005年第4期68-70,共3页
Acta Academiae Medicinae Jiangxi
关键词
原发性肝癌
乙型肝炎病毒
病理学
primary hepatic carcinoma
hepatitis B virus
pathology
