摘要
目的研究川芎嗪(TMP)对青霉素致痫大鼠大脑皮质及海马内一氧化氮合酶(NOS)表达的影响。方法使用青霉素致痫大鼠模型,采用BL-410生物机能实验系统记录双侧大脑皮层痫样放电,观察腹腔注射(ip)TMP,对癫痫大鼠大脑皮质及海马内NOS表达的影响。结果腹腔注射TMP后,大脑皮质及海马内NOS的表达较对照组明显降低,差异具有显著性意义。结论TMP能明抑制NOS的表达,具有抗癫痫作用。
Objective To study the influence of tetramethylpyrazine （TMP） on nitric oxide synthase （NOS） expression in the cerebral cortex and hippocampus of rats with penicilline-induced epilepsy. Methods Making use of epilepsy model in rats by penicillin ,using BL-410 data acquistion analysis system to record the seizure like discharge from bilateral cerebral cortices. After injection （ip） with TMP, the changes of NOS immu- noreaction in the cerebral cortex and hippocampus of rats were observed. Results After injection with TMP（ip） , the expression of NOS in cerebral cortex and hippocampus greatly declined compared with the seizure group, （ P 〈 0.05 ）. Conclusion TMP could have the function of restraining the seizure and significantly reduce the expres- sion of NOS.
出处
《咸宁学院学报（医学版）》
2005年第4期268-271,共4页
Journal of Xianning Univarsity(medical Sciences)
关键词
川芎嗪
癫痫发作
一氧化氮合酶
青霉素
大鼠
Tetramethylpyrazine
Seizure
Nitric oxide synthase
Penicillin
Rat
