摘要
目的探讨苦参碱注射液对乳腺癌化疗病人肝功能损害的保护作用。方法将78例乳腺癌患者进行的167例次化疗半随机分成苦参碱治疗组86例次和对照组81例次,治疗组在普通护肝治疗(对照组)的基础上,加用苦参碱每天150mg,静脉滴注连续2周,观察化疗前、化疗后第2周和第3周血清ALT、AST、GGT、STB的变化。结果对照组化疗后第2周血清ALT、GGT、STB较化疗前明显升高(P<0.05);对照组血清ALT、AST高于治疗组(P<0.05),但GGT和STB虽有升高,但两组差异无显著性(P>0.05);未发现苦参碱有明显的毒副作用。结论苦参碱注射液能降低乳腺癌化疗后病人血清ALT、AST、GGT、STB水平,并具有较好的保护肝功能作用,使用安全,副作用少,可作为预防乳腺癌化疗后肝损害的辅助用药。
Objective： To study the effect of matrine injection on preventing liver function damage of anti-tumor drugs during chemotherapy of breast cancer. Mehtods：167 times of chemotherapy were performed and divided into two groups （the control and treatment group： 86 times for the treatment one, 81 times for the control）, In control group, regular hepatinica was used,conbining with matrine injection 150 mg and infusion once a day for two weeks in treatment group. Serum levels of alamine aminotransterase（ALT） , aspartate amiotransferase（AST）, γ-glutamyl transfbrase（GGT）, Serum total bilirubin（STB） were tested before, after two weeks and after three weeks of chemotherapy in two groups. Results： The levels of ALT, AST, GGT, STB significantly increased （ P 〈 0. 05 ）. The levels of ALT and AST in control group were higher than that in treatment one. There were no severe slde-effects of matrine. Conclusion ： Matrine injection may be used safely and possess less side-effects on lowing serum levels of ALT, AST, GGT, STB in patients with breast cancer during chemotherapy so it can be used as adjuvant to prevent damages of the liver function for chemotherapy of patients with breast cancer.
出处
《中药材》
CAS
CSCD
北大核心
2005年第8期735-737,共3页
Journal of Chinese Medicinal Materials
