摘要
目的:探讨慢性乙型肝炎患者血清胆碱脂酶(CHE)活性水平与肝组织炎症病理分级(G)的关系.方法:采用RI-1000TM全自动生化分析仪检测106例经病理证实的慢性乙型肝炎患者血清胆碱脂酶(CHE)、丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)活性水平,统计分析血清ALT、AST、CHE水平与肝组织病理炎症分级(G0～G4)的关系.结果:血清CHE水平随着肝组织炎症活动度增高而降低,而ALT、AST水平随着肝组织炎症活动度增高而升高;G4级患者的血清CHE水平明显低于G1、G2、G3级患者,G3级低于G1、G2级,差异有显著性(P<0.05或0.01).G4级患者的血清AST水平明显高于G1、G2、G3级患者,但G1、G2、G3级患者AST水平以及各炎症分级之间ALT水平差异无显著性(P>0.05).结论:CHE比ALT、AST更能反映肝损害的严重程度,是一项有意义的无创性指标.
Objective： To investigate the relationship between serum cholinesterase （CHE） level and liver inflammation grade （G） in patients with chronic hepatitis B. Methods： 106 patients of chronic hepatitis B diagnosed and graded histopathologically with the needle biopsy were enrolled in this study. The serum levels of CI-tE. alanine aminotransferase （ALT） and aspartate aminotransferase （AST） were determined with RI-1000TM autochemical analyzer. The relationship between the serum levels of CHE, ALT and AST and the inflammation grade of liver（G0～G4）was statistically analyzed. Results： Following the exacerbation of hep atic inflammation . the CHE level decreased gradually, while the levels of AST and ALT increased gradually： the CHE level in G4 was obviously lower than in others （P〈0.01）, and the CHE level in G3 was lower than in G1 and G2 （P〈0.05）; AST level in G4 was obviously higher than in others （P〈0. 01）,but there was no difference of AST level among G1, G2 and G3： No difference of ALT level was found among all grades of hepatitis （P〉0.05）. Conclusion： Serum CHE level could be a useful and harmless index because it could reflect the severity degree of hepatitis better than did serum ALT and AST levels.
出处
《广东医学院学报》
2005年第5期513-515,共3页
Journal of Guangdong Medical College
关键词
乙型肝炎
慢性
胆碱酯酶类
肝脏/病理学
hepatitis B： CHE
alanine aminotransferase （ALT）
aspartate aminotransferase （AST）
