摘要
[目的]探讨针刺治疗中风性假性球麻疗的临床疗效及可能的作用机理。[方法]采用随机数字表法将75例中风性假性球麻痹患者随机分为针刺组、西药组和针刺加西药组,每组25例。针刺组给予针刺脑三针、舌三针、百会、通里和三阴交,西药组给予脑活素静滴和尼莫通口服,针刺加西药组既给予与针刺组相同的针刺治疗,又给予与西药组相同的药物治疗。治疗1个月后观察3组的临床疗效,并分别于治疗前和治疗后检测患者血浆6-酮-前列腺素F1α(6-keto-PGF1α)和血栓素B2(TXB2)的含量。[结果]针刺组的总有效率为96.00%,西药组为84.00%,针刺加西药组为96.00%,统计结果显示,针刺组和针刺加西药组疗效相仿(P>0.05),两组的疗效均优于西药组(P<0.05)。治疗后3组的血浆TXB2含量均明显降低,6-keto-PGF1α含量均明显升高(P<0.0(?));且针刺组和针刺加西药组的血浆TXB2含量降低和血浆6-keto-PGF1α含量升高作用均优于西药组(P<0.01)。[结论]针刺治疗中风性假性球麻痹的疗效确切,这可能与其改善患者的PGI2-TXA2的失衡状态有关。
[Objective] To observe the therapeutic effect of acupuncture for apoplectic pseudobulbar palsy （APP） and to explore its possible mechanism. [ Methods ] Seventy-five patients with APP were allocated to groups A, B and C by the method of random number table, 25 in each group. Group A was treated with acupuncture on acupoints of brain tripoints, tongue tri-points, Baihui, Tongli and Sanyinjiao; group B was treated with intravenous drip injection of cerebrolysin and oral use of nimotop; group C was treated with the combination of the above two. The therapeutic effect was evaluated after one-month treatment, and the plasma levels of 6-keto-prostaglandin F1α （6-keto-PGF1α） and thromboxane B2 （TXB2） were detected before and after treatment. [Results] The total effective rate was 96.00% in group A, 84.00% in group B and 96.00% in group C. The effect in group A did not differ from group C （ P 〉 0.05） while that in groups A and C differed from group B （ P 〈 0.05 ）. Plasma level of 6-keto-PGF1α increased and TXB2 level decreased obviously in the three groups after treatment （ P 〈 0.01 compared with those before treatment）, the changes of 6-keto-PGF1α and TXB2 level being much obvious in groups A and C as compared with group B （P 〈 0.01 ）. [ Conclusion] Acupuncture exerts an effect for the treatment of APP and its mechanism may be related to the regulation of imbalance of PGI2 and TXA2.
出处
《广州中医药大学学报》
CAS
2005年第5期369-372,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
