摘要
目的探讨羟基磷灰石骨水泥中碳酸根存在的意义及其对溶解度产生的影响。方法制备碳酸化羟基磷灰石骨水泥,定量分析其固化产物晶体中的碳酸根结构。以磷酸钙骨水泥为对照组,分别预制直径为8 mm、高为12 mm的圆柱体试样。经模拟体液浸泡后,定期观察、测量每一试样的失重率,对照分析其体外溶解性的差别。结果碳酸化羟基磷灰石骨水泥固化产物的晶体中含有质量浓度5.6%的碳酸根,与自然骨的矿物成分更接近。随着时间的改变,材料在模拟体液中逐渐由白色转为微黄色,棱角逐渐变钝。体视显微镜下观察发现材料表面出现点、坑、片状溶蚀,碳酸化羟基磷灰石骨水泥较磷酸钙骨水泥更明显。失重率的检测表明,酸化羟基磷灰石骨水泥的失重率改变明显高于磷酸钙骨水泥。结论羟基磷灰石骨水泥中碳酸根的存在可增加其溶解度,加快降解速度。
Objective To investigate the effect of carbonate ion on dissolution of hydroxyapatite cement in vitro. Methods A new type of carbonated hydroxyapatite cement was prepare and examined it＇s carbonate ion in the crystal lattice. Some standard rods were made by carbonated hydroxyapatite cement and calcium phosphate cement, and soaked into simulated body fluid at 37℃. As time went on, the weight change of each sample was tested in order to compare their dissolution. Results The carbonated hydroxyapatite cement contained 5.6 % carbonate ion after setting in situ. It＇s mineral component was similar to the natural bone. The surface changes of carbonated hydroxyapatite cement were more distinct than calcium phosphate cement. In vitro test of the rate of weight losses demonstrated that the dissolution of carbonated hydroxyapatite cement was better than the calcium phosphate cement. Conclusion Carbonate ion plays an important role in dissolution and degradation of hydroxyapatite cement.
出处
《生物医学工程与临床》
CAS
2005年第5期267-270,共4页
Biomedical Engineering and Clinical Medicine
基金
国家自然科学基金资助(编号:39670731)
关键词
碳酸根
磷酸钙
体外溶解
羟基磷灰石骨水泥
carbonate
calcium phosphate
dissolution in vitro
hydroxyapatite cement
