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链霉菌种间融合重组子产生的抗生素的分离和化学结构的确认 被引量:1

Isolation and Structural assignment of the antibiotic Produced by a recombinant
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摘要 从金色链霉菌和林可链霉菌的原生质体融合重组子产生的代谢物中,分离到1个抗菌组份。其薄层层析的Rf值,碳、氢、氮、氯及硫元素含量,红外吸收光谱和核磁共振谱的信号分析,证实其化学结构与半合成抗生素克林霉素同质。 The fermentation product of a recombinant which was produced by protoplast fusion between S lincolnensis var lincolnensis producing lincomycin and S.aureofaciens producing chlorotetracycline were isolated. The antibiotic obtained has the same element content, melting point and IR spectrum as those of clindamycin.The 1 ̄H-NMR(PMR)analyses indicate that it is identical with that of clindamycin which is a semisynthetic antibiotic.
出处 《中国抗生素杂志》 CAS CSCD 北大核心 1996年第1期1-4,共4页 Chinese Journal of Antibiotics
关键词 氯林可霉素 抗菌组份 融合子 链霉菌 化学结构 Clindamycin, Protoplast fusion, Recombinant
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