摘要
目的:海洛因依赖者常规脱毒一周左右,一次性给予大量纳曲酮冲击治疗,达到快速进入抗复吸治疗,提高操守率。方法:实验组40例,均为男性,常规脱毒7天,一次性给予纳曲酮50mg,辅以莨菪类药、氯丙嗪及镇静类药,使患者在睡眠中度过戒断期。心电监护,观察冲击治疗期及治疗后各项症状;比较治疗前后血常规、肝功能、肾功能、心电图改变情况。对照组40例,其性别、年龄、吸毒史、末周日滥用量与实验组基本一致,对两组均进行半年随访,比较两组操守率。结果:实验组入院至冲击治疗时间平均6.35天,一次性纳曲酮冲击成功率100%,冲击治疗期有P、R加快,BP升高,但均能顺利度过戒断期。冲击治疗清醒时间平均9.69h,术后戒断症状、药物副反应轻,消除快。对心、肝、肾、血常规没有明显影响。半年操守率,实验组30%明显高于对照组0%。结论:该法疗效肯定,安全性高,依从性好,很有临床实用价值,值得临床推广应用。
Objective： After detoxification for a week, heroin addicts were administered high dose ofnaltrexone so as to prevent relapse quickly and raise abstinence rate. Methods： 40 male cases were included in trial group. After general detoxification for 7 days, addicts were administered by naltrexone 50mg and combined with henbane drugs, chlorpromazine, sedatives and hypnotic drugs to avoid the trouble of withdrawal symptoms and maintain on sleeping state. ECG was monitored and every symptom was observed both during- and post-treatment. Routine blood exam, liver and kidney functions, ECG were assessed both pre- and post-treatment. Control group was a matched one by age, sex, history and doses of heroine abuse for trial group. Two groups were phoned for 6 months and compared with abstinence rates. Results： The average time from admission to treatment was 6.35 days. The cure rate of the therapy was 100%. Pulse, respiration, blood pressure increased at the course of duration in therapy. Those would disappear steadily. The average time of arousals was 9.69 hours. Withdrawal symptoms and side effects were cleared up quickly. This therapy had no significant influence on the functions of heart, liver, kidney and routine blood results. The abstinence rate in 6 months in trial group （30%） was higher than that of the control group （0%）. Conclusion： This therapy is efficient and safe. Patients comply with the therapy. The therapy may be spread in clinic.
出处
《中国药物滥用防治杂志》
CAS
2005年第4期193-197,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
湖南省卫生厅资助课题(B2004-131)
