摘要
目的:揭示桂麻合方解热作用协同、拮抗关系的存在及产生的原因。方法:以耳缘静脉注射内毒素复制家兔发热模型,测量口服桂枝汤、麻黄汤及其合方后不同时间的体温采集耳缘静脉血,血液样品按环磷酸腺苷(cAMP)、前列腺素E2(PGE2)药盒要求处理。结果:家兔血中的PGE2和cAMP的变化与体温变化相平行,解热作用有协同或拮抗关系的存在。结论:桂麻合方在煎煮过程中的新整合对PGE2和cAMP含量产生影响,从而使其解热作用出现协同或拮抗关系。
Objective：To reveal the existence of antagonistic or synergistic relationship between compositions of Ma huang and Gui-zhi decoction and the reason. Methods： Copy the family rabbit fever model by iv endotoxin （ET） , take the temperature at different time points after administering Gui-zhi decoction, Ma-huang decoction and their compositions, and then collect the vein blood, detect the cAMP and PGE2 in sample according to the specification. Results：The changes of the levels of PGE2 and cAMP are paralleled to the change of temperature. There exists an antagonistic of synergistic relationships in the deferveseenee effect. Conclusion：The new integrations produced in the process of deeocting of Gui-ma composite decoctions have influences on the levels of PGE2 and cAMP, which makes the deferveseenee effect produce the antagonistic or synergistic relationship.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2005年第10期945-946,共2页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金项目(No.30371723)
国家中医药管理局项目(No.02-03JP-08)
