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大鼠局部脑缺血再灌注下丘脑CRH和BDNF的表达 被引量：4

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摘要 目的探讨局部脑缺血/再灌注(I/R)对下丘脑促肾上腺皮质激素释放素(CRH)、脑源性营养因子(BDNF)和下丘脑-垂体-肾上腺轴(HPA轴)的影响。方法采用免疫组化方法对老龄大鼠局部脑缺血下丘脑的CRH和BDNF表达进行动态观察。结果假手术对照组大鼠下丘脑有少量CRH和中量BDNF表达;I/R 1 h内CRH和BDNF表达无明显变化;I/R 6 h CRH表达出现短暂一过性消失,随后迅速恢复表达,并增至中量表达;I/R 6 h后BDNF很快呈大量表达。结论下丘脑是富含BDNF的脑组织,脑缺血后CRH分泌细胞并非立刻进入活动增强状态;脑缺血2d后CRH分泌细胞活动进入增强期;下丘脑BDNF的含量与CRH的含量呈正相关;BDNF对维系HPA活动状态可能具有重要作用。
作者 李爱丽 孟晓萍 杨文 李会媛 孙海燕 刘娜
机构地区 吉林大学第二医院神经内科 吉林大学第二医院心血管科 吉林大学第二医院内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2005年第9期1073-1075,共3页 Chinese Journal of Gerontology
基金 吉林省科技厅资助课题(200001) 长春市科技局资助课题(2001-12)
关键词 局部脑缺血 大鼠 BDNF CRH HPA
分类号 R363.21 [医药卫生—病理学]
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参考文献7

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二级参考文献30

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共引文献10

同被引文献66

  • 1任晓霞,康玉明.中枢氧化应激对心血管疾病的影响[J].心血管病学进展,2009,30(6):1023-1026. 被引量：3
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  • 3陈伟峰,韩继媛,田兆兴,曹锋生.复方麝香注射液在大鼠急性缺血再灌注损伤中对BDNF和NGF的影响[J].广西中医学院学报,2005,8(3):8-10. 被引量：8
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引证文献4

二级引证文献48

中国老年学杂志
2005年 第9期

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