摘要
目的观察血必净对危重病患者血管内皮细胞的保护作用。方法将70例危重病患者随机分为西医综合治疗组(对照组)和西医综合治疗+血必净组(血必净组)。对照组给予抗生素、营养支持、血液净化、呼吸机等综合治疗。血必净组给予综合治疗的同时,加用血必净注射液100ml静滴,2次/d。两组患者分别在入院当时及治疗第2、5、7d用ELISA法检测血浆血栓调节蛋白(TM)及血管性血友病因子(VWF),并与正常者比较。结果入院时对照组及血必净组患者TM、VWF的均值均显著高于正常者(P<0·01)。血必净组两指标在治疗第5、7d明显低于对照组(P均<0·05);第7d血必净组两指标接近正常者,APACHEⅢ评分、临床生化指标及多脏器功能障碍综合征(MODS)发生率均明显低于对照组(均P<0·05)。结论血必净注射液对危重病患者血管内皮细胞有保护作用。
Objective To study the protective effect of Xuebijing on the vascular endothelium of critical patients. Methods Seventy critical patients were randomly divided into 2 groups： routine western medicine treatment group （control group） and western medicine combined with Xuebijing treatment group （Xuebijing group）. In control group, patients were treated with antibiotics, nutrition sustained, blood purification, mechanical ventilation ect. In Xuebijing group, patients were treated with western medicine and intravenous Xuebijing injection 100ml, twice per day. Plasma thrombomodulin （TM） and von Willebrand factor （vWF） were both measured with ELISA in all patients on admission to hospital and on the 2nd, 5th, 7th day respectively. Results Plasma levels of TM and vWF were markedly higher in control group and Xuebijing group than in normal group on admission to hospital （all P 〈0. Ol ）. And there were significantly decreased in Xuebijing group compared to the control group in the 5th and 7th days （ all P 〈0. 05）. Furthermore, there was no difference on the 7th day between Xuebijing group and the normal group about TM and vWF. APACHEⅢ scores, clinical biochemical indexes and incidence of multiple organ dysfunction syndrome （MODS） in Xuebijing group were significantly lower than those in control group in the 7th day （ all P 〈 0. 05）. Conclusion Xuebijing injection has protective effect to the vascular endothelium of critical patients, the efficiency of Xuebijing group was superior to control group in critical patients.
出处
《中国全科医学》
CAS
CSCD
2005年第18期1486-1487,共2页
Chinese General Practice
