摘要
目的探讨2型糖尿病患者血浆同型半胱氨酸(homocysteine,Hcy)水平与糖尿病视网膜病变之间的关系。方法测定45例2型糖尿病(DM)患者及19例健康对照者(CON)血浆同型半胱氨酸水平,45例2型糖尿病患者分为糖尿病视网膜病变(DR)组(17例)与无视网膜病变(NDR)组(28例),比较各组间血浆总Hcy的水平;再将17例DR组分为增殖期糖尿病视网膜病变(PDR)组(9例)和背景期糖尿病视网膜病变(BDR)组(8例),比较两组间血浆总Hcy的水平。结果2型糖尿病患者中DR组的血浆总Hcy水平高于NDR组及CON组(P<0.01),NDR与CON组比较则无显著性差异。在DR组,PDR组的血浆总Hcy水平显著高于BDR组(P<0.01),以正常对照组的血浆Hcy均数+2个标准差作为高Hcy血症的诊断标准,PDR组高Hcy血症的发生率高于BDR组(P<0.05)。结论2型糖尿病患者伴有视网膜病变者血浆总Hcy水平升高,其中PDR组的血浆总Hcy又高于BDR组。血浆总Hcy水平升高,可能是2型糖尿病视网膜病变的危险因素之一。
Objective To explore the relationship between the lever of serum homocysteine （Hcy） and retinopathy in type 2 diabetes mellitus. Methods The level of serum homocysteine （Hcy） was measured in type 2 diabetes mellitus group of 45 and in healthy contrast group of 19. 45 cases were divided into diabetic retinopathy （ DR, 17 cases） and no - diabetic diabetic group （NDR, 28 cases）. At the same time in DR group , 17 case were divided into proliferative phase DR group（PDR, 9 cases） and background DR group （BDR, 8 cases）. Results The level of serum Hcy in DR group was higher than that of in NDR group and CON group respectively （p 〈 0.01） ,while there was no significant difference between NDR group and CON group .The level of serum Hcy in PDR group was higher than that of in BDR group （p 〈 0.01 ）. Conclusion The level of serum Hcy was increased in type 2 diabetes mellitus combined with retinopathy and it maybe one of risk factor for 2 diabetes mellitus to develop retinopathy.
出处
《浙江临床医学》
2005年第9期907-908,共2页
Zhejiang Clinical Medical Journal
