摘要
探讨蒽环类化疗药物剂量强度与心脏耐受性的关系,对68例局部晚期乳腺癌患者应用不同剂量强度的CEF(5-FU+表阿霉素+环磷酰胺)联合化疗方案,通过检测患者心电图及心功能的变化,临床对照观察患者的心脏毒性反应。表阿霉素低剂量(50mg/m2)组较少出现心电图异常,3例心电图一过性改变者,较快(2周内)恢复正常。高剂量组(75mg/m2)5例心电图改变,有3例在2周内恢复正常,1例有所减轻,但1例在2周后无改善,后经超声心动图检测诊为充血性心力衰竭。初步研究结果提示,大多数患者能够较好地耐受高剂量的CEF化疗方案。
The objective of this research was to study the relationship between the doses of anthracycline and tolerance in patients with breast cancer. Sixty-eight patients with local advanced breast cancer who received different dose of anthracycline-containing regimens were observed for the cardiotoxicity according to the change of electrocardiogram and echocardiography. The results were treated statistically hy using X^2 test, There were few patients with abnormal electrocardiogram in the low dose group （50 mg/m^2 ）. and among them 3 patients had transient electrocardiogram changes and quickly recovered in 2 weeks. Five patients with abnormal electrocardiogram in the high dose group （ 75 mg/m^2 ） were detected, and among them 3 patientS recovered in 2 weeks, patiem＇s symptom relieved partialy and patient was diagnosed as congestive heart failure by eehoeardiography. In eonclusinn, the patients have similar tolerance in two groups, P〉 0. 05. The most patients show good tolerance of high dose of anthracyeline-containing regimens.
出处
《肿瘤防治杂志》
2005年第18期1403-1404,共2页
China Journal of Cancer Prevention and Treatment
关键词
乳腺肿瘤/药物疗法
蒽环类/药理学
抗肿瘤药/治疗应用
预后
breast neoplasms drug theratpy
anthracyclines pharmacology
antineoplastic
agents therapeatic uses
pragnsis
