摘要
目的探讨氢质子磁共振波谱分析(1H-MRS)在碘异常引起脑损伤病变中的应用价值。方法收集临床诊断碘异常引起脑损伤的病例28例,其中低碘组16例,高碘组12例。使用西门子1.5 T MRI,多体素相位矩阵扫描。检测低碘组和高碘组病人海马区与正常参照区域的代谢物浓度,利用SPSS12.0分析各种代谢物的变化。结果1H-MRS示低碘组胆碱降低、γ-氨基丁酸、N-乙酰天门冬氨酸减少;高碘组胆碱增加、谷氨酸升高,γ-氨基丁酸、N-乙酰天门冬氨酸减少。结论1H-MRS在碘异常引起脑损伤病变定性诊断中有重要的临床价值。
Objective To evaluate the value of ^1H - MRS in brain damage which induced by abnormal iodine. Methods Collected twenty - eight patients with brain damage of abnormal iodine. All patients were divided into low iodine group and high iodine group. Multivoxel proton MRS was performed on SIEMENS novus 1.5T MRI . Spectra of hippocampus and normal white matter were evaluated in every patients. Fitted areas in the spectrum for N - acetylaspartate （NAA） , choline （Cho） , creatine （Cr） , Glutathione （Glu） , gamma amino butyl aicd （GABA） metabohte peaks were measured for each voxel. SPSS 12.0 for windows was used for statistical analysis metabohte in different regions. Results Cho, GABA and NAA showed significantly absent in cases of low iodine group than normal appearing white matter. Cho, Glu was significantly higher and GABA, NAA were lower in cases of high iodine group than normal appearing white matter. Conclusions ^1H - MRS Ires important chnical application value in diagnosis of brain damage induced by abnormal iodine.
出处
《中国地方病防治》
北大核心
2005年第5期263-265,共3页
Chinese Journal of Control of Endemic Diseases
关键词
低碘
高碘
质子磁共振波谱
脑损伤
Low iodine
High iodine
Proton magnetic resonance spectroscopy（ ^1 H - MRS）
Brain damage
