摘要
明胶具有生物降解性及良好的生物相容性,已被广泛用于照相、食品及医药工业.为开发明胶的新用途,用乙二胺四乙酸酐(EDTAD)成功地对明胶进行了乙酰化改性,研制出了酰化明胶水凝胶,用紫外-可见分光光度法确定了酰化反应的工艺条件为:调节w(明胶)＝1%水溶液的pH到12,在室温下反应2～3 h.酰化后明胶溶液的等电点向低pH方向移动,改性明胶所生成的水凝胶达到溶胀平衡所需的时间大幅度减小,平衡溶胀率呈几十甚至几百倍提高,且当m(EDTAD):m(明胶)＜1:15时,随着酰化剂用量的增加,改性明胶水凝胶的平衡溶胀率最高可达110左右.且水凝胶具有pH敏感性和离子强度敏感性,pH敏感点为pH ≈4.
Gelatin is biodegradable and biocompatible, and has been widely used in photography, food and drug industry. In order to make new use of gelatin, the lysyl residues of gelatin was modified with ethylenediaminetetraacetic dianhydride （EDTAD） followed by cross-linking with glutaraldehyde. The acylation process was studied via UV-vis spectrometer,and the reaction conditions were determined to be pH 12, room temperature and 2 - 3 h. It is found that hydrogels made from acylated gelatin are fastswelling compared with those made from gelatin. When m （EDTAD）：m （gelatin） 〈 1：1 5, with increasing amount of EDTAD, swelling ratio （SR） of the hydrogel increases greatly, and the highest SR value could reach I I0. The pH-sensitive point of the hydrogel is at pH 4, corresponding to the isoelectrical point of acylated gelatin. The hydrogels are also ionic strength-sensitive, which could be of great use for controlled drug delivery system.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2005年第10期739-743,共5页
Fine Chemicals
基金
国家自然科学基金资助(批准号:20374040)~~
