摘要
目的探讨经皮选择性肝脏隔离灌注化疗(PSIHP)的可行性及隔离效果。方法实验猪8头,利用介入放射学方法进行经皮选择性肝脏隔离灌注化疗结合血液灌流。化疗药物选用5-FU。比较灌注区域肝细胞形态和凋亡指数。结果灌注区域肝细胞损伤明显,肝细胞凋亡指数[(52.83±5.12)%]明显高于未灌注区域肝细胞凋亡指数[(3.52±0.96)%](P<0.01)。结论PSIHP是一种简单有效的肝脏隔离灌注化疗技术,隔离效果佳,对未灌注区域肝组织有良好的保护作用。
Objective To investigate the feasibility and the efficacy of percutaneous Selective Isolated Hepatic Perfusion Chemothempy（PSIHP）. Methods Eight pigs underwent PSIHP with 5 - FU by interventional radiologic method. The morphology and apoptoticindx（AI） of hepatic cells of the perfusion and non-peffusion hepatic tissue were investigated. Results Hepatic cell damage was severe in the peffusion hepatic tissue and the AI was significantly higher in perfusion hepatic tissue（52.83 ± 5.12 % ） compared with the non - peffusion hepatic tissue [ （3.52 ± 0.96 ） % ] （ P 〈 0.01 ）. Conclusion PSIHP is a simple and feasible method for Isolated Hepatic Peffusion and has excellent isolation effects and satisfactory protection to non- perfusion regional liver.
出处
《广东医学》
CAS
CSCD
北大核心
2005年第10期1334-1335,共2页
Guangdong Medical Journal
基金
深圳市科技局基金资助项目(编号:200104087)
