摘要
目的:分析POF患者血清中相关性激素FSH、LH、E2、P的水平变化及临床发病率.方法:应用电化学发光免疫分析技术(ECLIA),从711名测定激素的女性中,选取临床确诊、检测结果符合诊断的POF患者23例,围绝经期患者21例进行比较.结果:POF(A组35岁以下,B组35～40岁)FSH水平均值升高,与围绝经期FSH均值(C组41～45岁)比较,P＞0.0 5.A、B两组E2水平均值下降,与C组比较,P＞0.05.LH、P两项激素的水平均值,A、B、C 3组之间差别不大,结果均显示LH升高,P下降.A组4项激素检测结果标准差均明显大于B、C两组.A、B两组占总数的3.2%.结论:POF患者血清中FSH、LH水平明显升高,而E2、P则相应降低.A组激素水平不稳定性较大.本组资料临床发病率3.2%,支持POF发病率有上升趋势这一观点.
Objective： The level variety of the relativity sex hormone FSH, LH, E2, P in analytical premature ovarian failure sufferer＇s serum, and clinical outbreak rate. Methods： Applying the electrochemistry luminescence immunity analysis technique （ECLIA） , from the female inside of 711 determinations hormone, select by examinations the elinieal certain, examine the result to match diagnostic 23 of sufferer of POF, 21 of sufferer of peri - menopause. Results： ①POF （ the set of A： Under 35 years old, the set of B： 35-40 years old） the level of FSH all is worth to go up, all being worth （ C set： 41 -45 years old） the comparison with the peri - menopause. （ P 〉0. 05）. A, B Two E2 levels all be worth to descend, comparing with C set （P 〉0. 05）. LH, P two levels of hormone all be worth. A, B, C three a differences of the sets are not big, the result all shows that the LH go up, the P descend. Four hormones of A set examination result standard deviation （S） , all obvious and big in B, C two. ②A, B two the sets have to amount the percentage as 3.2%. Conclusion： POF sufferer the serum inside FSH, LH level goes up obviously, but E2 , P then the cowgirl lowers. A hormone level unsteady compare greatly. 3.2% of this text clinic outbreak percentage, the support POF outbreak rate has the up-trend this standpoint.
出处
《中国妇幼保健》
CAS
北大核心
2005年第19期2568-2569,共2页
Maternal and Child Health Care of China
关键词
卵巢早衰
性激素
电化学
Premature ovarian failure
Sex hormone
ECLIA
