血清性激素结合球蛋白与多囊卵巢综合征糖代谢的相关研究被引量：8

Association of Serum Sex Hormone-binding Globulin with Glycometabolic Parameters in Polycystic Ovary Syndrome

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摘要目的:探讨血清性激素结合球蛋白(SHBG)与多囊卵巢综合征(PCOS)患者糖代谢的关系及干预治疗对其影响。方法:以16例正常育龄妇女为对照组,69例PCOS患者分为3组:非胰岛素抵抗(NIR)组、高胰岛素血症(HI)组、异常糖代谢(AMG)组,其中6例患者接受12周二甲双胍联合体育锻炼干预治疗,免放法测定血清SHBG水平。分别比较4组SHBG水平,分析SHBG与BMI、腰围、血压、Homa-IR、胰岛素敏感指数(ISI)等因素的相关性。结果:SHBG水平:HI、AMG>NIR>对照组;BMI、Homa-IR:AMG>HI>NIR组(P<0.01);ISI:AMG<HI<NIR(P<0.01)。PCOS患者SHBG水平与FINS、Homa-IR、BMI、腰围、AUIC及TG负相关(P<0.01及P<0.05);与ISI正相关(P<0.01)。控制BMI影响后SHBG水平仍与Homa-IR负相关(P<0.01)。干预治疗后,SHBG、ISI上升,血压及睾酮水平降低。结论:低血清SHBG可能是高危PCOS的预示因子,但不是一个敏感指标;干预治疗可改善胰岛素敏感性、提高SHBG水平,有助于降低高危PCOS糖代谢进展的危险。 Objective： To explore the correlation of serum sex hormone-binding globulin （SHBG） with glycometabolic parameters in PCOS and their changes by intervention. Methods： 16 normal reproductive-aged women as controis, and 69 PCOS patients were divided into three groups： normal glucose tolerance without hyperinsulinemia （NIR）, hyperinsulinemia （HI）, and abnormal glucose metabolism （AGM） according to their oral glucose tolerance test and insulin release test; 6 AGM patients were treated by combined Metform and exercise for 12 weeks. Serum SHBG levels was measured by ELISA. SHBG level and other glucose metabolic parameters （BMI, Homa-IR, ISI） were compared among groups. Results： SHBG level： HI group AMG group 〉 NIR group 〉 control. In PCOS patients, BMI and Homa-IR： AMG〉 HI〉 NIR group （P〈0.01）; ISI： AMG〈HI〈 NIR （P〈0.01）; SHBG level was negatively correlated with FINS, Homa-IR, BMI, waist circumference, IAUC and TG （ P 〈 0.01 and P 〈 0.05）, but positively related with ISI （ P 〈 0.01 ） ; After control the influence of BMI, SHBG level was negatively correlated with Homa-IR also （ P〈 0.01 ）. After 12-week intervention in six AGM patients, their serum SHBG and ISI increased but serum T and blood pressure decreased, with no statistic significance （ P 〉 0.05）. Conclusions： Lower serum SHBG level in PCOS patients might be a sign but not a sensitive indicator for high risk. Intervention treatment can improve insulin sensitivity, increase SHBG level, and may be lower the abnormal glycometabolic progression at highrisk PCOS patients.

作者赵君利陈子江赵力新马增香唐蓉李媛

机构地区宁夏医学院附属医院山东大学山东省立医院

出处《实用妇产科杂志》 CAS CSCD 北大核心 2005年第10期608-611,共4页 Journal of Practical Obstetrics and Gynecology

关键词性激素结合球蛋白多囊卵巢综合征糖代谢胰岛素抵抗 Sex hormone-binding globuli Polycystic ovary syndrome Glycometabolism Insulin resistance

分类号 R711.75 [医药卫生—妇产科学]

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