摘要
目的:以君药效应成分伪麻黄碱(pseudo-ephedrine,PE)为指标,用GC-MS法考察不同配伍对PE药代学参数的影响规律,探索麻黄汤方中臣佐使药对君药人体内过程的影响。方法:对麻黄汤作正交设计拆成8个配伍组,每组8名健康男性志愿者,服药后在不同时间点抽取静脉血,测定血清中PE的含量,绘制药-时曲线;选用药代软件Win-Nonlin4.0.1求算药代学参数;采用SPSS10.0软件对药代参数进行统计分析。结果:所有药时曲线均符合无滞后开放式一房室动力学模型;不同配伍对PE的部分药代学参数有显著影响(P<0.05);方中各药味对PE的部分药代参数的影响有显著交互作用(P<0.05)。结论:臣佐使药对方中君药有效成分伪麻黄碱的药代学参数有一定影响。
Objective： To develop a GC-MS method for the determination of pseudo-ephedrine in human plasma and study the mutative rules of the pharmacokinetic parameters of the pseudo-ephedrine in different compositions. Method： Orthogonal design was used to determine 8 compositions from Mahuang decoction （MILD）. The healthy vohmteers were divided into groups in random, each group including 8 men. After taking the medicine orally, vena blood would be taken out at different time. Determining pseudo-ephedrine in plasma and plotting the concentration-time curve, the pharmacokinetic parameters of each composition were calculated by WinNonlin 4.0.1. The statistical analysis of the pharmacokinetic parameters was proceeded by SPSS 10.0. Result： All concentration-time curves were adequately modeled by one comportment, first order absorption model, no lag time. Some parameters of pseudo-ephedrine showed significant variance （P 〈 0.05） in different compositions. The statistic results showed interactions between drugs in MIlD （ P 〈 0.05）. Conclusion： The other herbs erds of MIlD have some certain extent effects to the pharmacokinetic parameters of pseudo-ephedrine in the dominant drug.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第18期1454-1457,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金重点资助项目(30030150)
关键词
麻黄汤
药代学
伪麻黄碱
配伍
组方原理
Mahuang decoction
pharmacokinetics
pseudo-ephedrine
compatibility
composition principle
