摘要
目的检测在慢性阻塞性肺疾病(COPD)和支气管哮喘患者血浆和痰液中P物质(SP)的含量及探讨其作用。方法收集了26例COPD、20例哮喘和12例健康者的血浆及诱导痰标本,采用放射免疫分析法检测SP的浓度。结果COPD组血浆及痰液SP浓度分别为(7.9±2.6)和(53.8±12.5)pmol/L,明显高于对照组的(3.6±1.7)和(6.2±2.3)pmol/L,(P<0.01);哮喘组血浆及痰液SP浓度分别为(8.3±3.1)和(46.9±10.2)pmol/L,也明显高于对照组(P<0.01);COPD和哮喘组间SP浓度无显著性差异(P>0.05)。结论SP可能参与了COPD和哮喘的发病过程。
Objective To investigate the role of substance P （SP） in chronic obstructive pulmonary disease （COPD） or asthma. Method Plasma and sputum samples were obtained from 26 COPD patients and 20 asthmatic patients as well as 12 healthy subjects for measurement of SP content. Results Patients with COPD had significantly higher levels of SP in the plasma （7.9± 2.6 pmol/L） and sputum （53.8±12.5 pmol/L） than the healthy subjects （3.6±1.7 pmol/L and 6.2±2.3 pmol/L, respectively, P〈0.01 ）. The asthmatic patients also had significantly higher SP levels （8.3±3.1 pmol/L and 46.9±10.2 pmol/L, respectively） than the healthy subjects, but there was no significant difference between COPD and asthmatic patients （P〉0.05）. Conclusion SP may be involved in the airway inflammation process in COPD and asthma.
出处
《第一军医大学学报》
CSCD
北大核心
2005年第10期1314-1315,共2页
Journal of First Military Medical University
关键词
阻塞性肺疾病
支气管哮喘
P物质
chronic obstructive pulmonary disease
asthma
substance P
