摘要
冠状动脉内安放支架具有操作简便、疗效明显等特点,但由于支架本身是一种金属异物,可以导致血栓的形成和引起机体的免疫反应。因而术后亚急性血栓形成和再狭窄仍是两大主要并发症。而药物涂层支架属于药物洗脱性聚合物涂层支架,即在金属支架表面涂以某种聚合物,并在此基础上结合一种有治疗作用的药物或抗体,将药物运送到病变部位提高局部药物浓度,达到治疗目的。本文综述了药物涂层支架相关问题的研究进展。
Emplacing a stent in the coronary artery has many characteristics. The installation is easy to do and the stent has evident curative effect. However, it will cause thrombosis and immunoreaction because it is metal. So suhurgent thrombosis and restenosis after surgeries are still two major complications. The drug-coated stent is one kind of the drug-eluting stents, whose metal surface is coated by some polymer that combines with a sort of effective drug or antibody. It can transport the drug or antibody to the localily of pathological changes and there in it improves the local drug concentration. In this paper the research progress of interrelated issues about the drugcoated stent is reviewed.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2005年第2期389-391,共3页
Journal of Biomedical Engineering
基金
重庆市重点高新技术项目资助 (渝计委技 [2 0 0 2 ] 15 71号 )
