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高甘油三酯血症患者脂联素水平与胰岛素抵抗相关性研究 被引量:8

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摘要 入选对象90例,分为高甘油三酯组(HT)和低甘油三酯组(LT)。评价颈总动脉内膜-中层厚度(IMT)等指标的水平。结果HT组腰臀比(WHR)、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白B(APOB)、空腹血糖(FBG)、空腹胰岛素(FIns)和HOMA-IR水平高于LT组,高密度脂蛋白-胆固醇(HDL-C)低于LT组(P<0.05)。HT组IMT、血浆致动脉硬化指数(AIP)高于LT组,脂联素水平低于LT组(P<0.001)。Spearman相关分析显示,脂联素与HDL-C(r=0.342,P=0.001)和载脂蛋白A1(APO-A1)(r=0.295,P=0.005)呈正相关;与AIP(r=-0.302,P=0.004)和TG(r=-0.285,P=0.007)呈负相关。在校正BMI、体内脂肪含量(BFC)、WHR后,脂联素仍然与AIP呈负相关(r=-0.244,P=0.024)。结论:高甘油三酯血症患者脂联素水平降低,并且低脂联素与脂代谢紊乱和动脉粥样硬化密切相关。
出处 《实用糖尿病杂志》 2005年第5期37-39,共3页 Journal of Practical Diabetology
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参考文献11

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二级参考文献23

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