摘要
目的探讨听觉事件相关电位(ERP)在帕金森氏病痴呆(PDD)和血管性痴呆(VD)中的差异以及意义。方法对23例VD患者,16例PDD患者及20位正常人检测ERP,进行对照分析。结果3组间ERP异常程度不同,VD组与PDD组P3潜伏期均较对照组显著延长(P<0.05),而VD组P3延长较PDD组更明显(P<0.05)。N2组间异常程度不同,VD组较PDD组N2潜伏期延长,波幅降低(P<0.05)。ERP的外源成份N1异常程度不同,VD组N1潜伏期延长,波幅降低,与正常对照组相比,差异显著(P<0.05),而PDD组N1潜伏期、波幅与正常对照组相比无显著差异。结论VD、PDD患者听觉ERP的外源、内源成份皆有差异。ERP检测对临床痴呆类型的鉴别,有一定的参考价值。
Objective To compare the auditory event- related potential（ERP） in vascular dementia（VD） patients with Parkinson dementia（PDD） patients. Methods ERP was measured in 23 VD patients, 16 PDD patients and 20 healthy people. Results Prolonging of P3 is more obvious in VD group than that in PDD group （ P 〈 0.05）. Compared with normal group, the incubation period of Nl, which is the composition of ERP＇ s external cause, is longer and the amplitude of N1 is lower in VD group than those in control group. But both incubation period and amplitude of N1 in PDD group are normal. Conclusions Compositions of ERP＇s external cause and internal cause between VD and PDD patients are different. Measurement of ERP is vsluable for diagnosis of clinical dementia＇s type,
出处
《心脑血管病防治》
2005年第5期11-13,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词
血管性
帕金森病
痴呆
事件相关电位
Vascular dementia
Parkinson dementia
Auditory event- related potential（ERP）
