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抗肿瘤核糖核酸酶Onconase研究进展 被引量：5

Progresses on research of Onconase : An anti-tumor ribonuclease
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摘要 Onconase是第一个进入Ⅲ期临床研究的核糖核酸酶药物,用于治疗恶性间皮瘤。属于RNase A超家族,RNase活性低,细胞毒性强,体内、体外对多种肿瘤具显著杀伤作用;同时具有抗病毒活性,尤其是抗人类免疫缺陷病毒功能是今后研究和开发的重点。此文综述了Onconase的研究历史与现状,包括Onconase的结构和功能之间的关系,抗肿瘤、抗病毒作用的机制,药物开发进展、毒副反应等。
作者 秦孙星 李晓波
机构地区 上海交通大学药学院
出处 《中国生化药物杂志》 CAS CSCD 2005年第5期309-311,共3页 Chinese Journal of Biochemical Pharmaceutics
关键词 ONCONASE 核糖核酸酶 抗肿瘤 抗病毒 Ⅰ型人类免疫缺陷病毒
分类号 Q55 [生物学—生物化学] R979.1 [医药卫生—药品]
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参考文献20

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同被引文献77

  • 1钱敏,李关荣,鲁成.核糖核酸酶研究进展[J].蚕业科学,2004,30(2):185-190. 被引量：10
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  • 3黄强,陈利弘,曾令宇,万琳,李胜富,卢晓风,程惊秋.大肠杆菌表达的人源性抗CTLA4单链抗体三种复性方法比较[J].生物医学工程学杂志,2006,23(2):388-391. 被引量：3
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引证文献5

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中国生化药物杂志
2005年 第5期

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