摘要
目的:观察通里攻下法对多器官功能障碍综合征(M ODS)或全身炎症反应综合征(S IRS)模型动物内毒素血症的影响。方法:40只纯种新西兰大白兔随机分为实验组和对照组,每组20只。用W iggers方法制成失血性休克模型,观察并记录M ODS或S IRS的发生率。实验组家兔每日经口灌服大承气颗粒剂1.25 g,连续3 d。所有动物于休克前及休克后1、3、7 d取血测定血清内毒素水平。结果:40只兔中29只(72.5%)发生M ODS。治疗后对照组内毒素水平呈升高趋势,而实验组呈下降趋势,实验组内毒素在治疗后7 d显著低于对照组(P<0.01)。结论:使用大承气颗粒能够控制严重创伤所致M ODS或S IRS模型动物内毒素血症。
Objective： To observe the therapeutic effect of removing stasis by purgation （通里攻下）on endotoxemia in multiple organ dysfunction syndrome （MODS） or systemic inflammatory response syndrome （SIRS） models. Methods： Forty New Zealand rabbits were randomized into two groups： experimental group （n=20） and control group （n=20）. Hemorrhagic shock models were made by means of Wiggers. Incidence of MODS or SIRS was recorded in all rabbits. The experimental group received 1.25 g Dachengqi granule （大承气颗粒） every day for 3 days. Blood samples were taken from all rabbits before and 1, 3, 7 days after hemorrhagic shock to detect endotoxin level. Results： MODS occurred in 29 rabbits （72.5%）. The trend of increase was observed in endotoxin level in control group, while the trend of decrease was observed in endotoxin level of experimental group. The level of endotoxin in experimental group was significantly lower than that of the control group at 7 days after hemorrhagic shock （P〈0.01）. Conclusion：Dachengqi granule can effectively control the endotoxemia in MODS or SIRS models induced by severe trauma.
出处
《中国中西医结合急救杂志》
CAS
2005年第5期286-288,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
天津市"九五"重点攻关课题(983113411)
关键词
创伤
内毒素
中医药
实验研究
trauma
endotoxin
Chinese traditional medicine
experimental investigation
