期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肠免疫组织对肠上皮细胞生长的影响 被引量：2

在线阅读 下载PDF
导出
摘要 肠粘膜免疫组织除了发挥免疫功能外,还能通过分泌多种细胞因子调节肠上皮细胞受损后的再生和修复。其中,在二者间起重要交流作用的细胞因子是IFN-γ,此外IL-2和IL-4也对维持正常的粘膜免疫和肠上皮细胞发挥重要调节作用。这些细胞因子调节上皮细胞增殖和分化的机制之一通过上皮细胞表面受体激活JAKs激酶,随后激活包括转录蛋白STAT家族在内的各种不同的信号蛋白,从而表达细胞因子功能。
作者 付凯飞 彭瑞云
机构地区 [ 军事医学科学院放射医学研究所
出处 《国外医学（免疫学分册）》 2005年第6期328-331,共4页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
基金 全军"十五"医药卫生科研基金指令性项目(01L019)
关键词 肠上皮细胞 细胞因子 机制
分类号 R392.1 [医药卫生—免疫学]
  • 相关文献

参考文献20

  • 1Okazawa A,Kanai T,Nakamaru K,et al.Human intestinal epithelial cell-derived interleukin (IL)-18,along with IL-2,IL-7 and IL-15,is a potent synergistic factor for the proliferation of intraepithelial lymphocytes[J].Clin Exp Immunol,2004,136(2):269-276.
  • 2Mysorekar IU,Lorenz RG,Gordon JI.A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes[J].J Biol Chem,2002,277(40):37811-37819.
  • 3Chen Y,Chou K,Fuchs E,et al.Protection of the intestinal mucosa by intraepithelial gamma delta T cells[J].Proc Natl Acad Sci USA,2002,99(22):14338-14343.
  • 4Matsumoto S,Nanno M,Watanabe N,et al.Physiological roles of gammadelta T-cell receptor intraepithelial lymphocytes in cytoproliferation and differentiation of mouse intestinal epithelial cells[J].Immunology,1999,97(1):18-25.
  • 5Hess DJ,Henry-Stanley MJ,Erickson EA,et al.Effect of tumor necrosis factor alpha,interferon gamma,and interleukin-4 on bacteria-enterocyte interactions[J].J Surg Res,2002,104(2):88-94.
  • 6Zachrisson K,Neopikhanov V,Samali A,et al.Interleukin-1,interleukin-8,tumournecrosis factor alpha and interferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines[J].Eur J Gastroenterol Hepatol,2001,13(5):551-559.
  • 7Bruewer M,Luegering A,Kucharzik T,et al.Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms[J].J Immunol,2003,171(11):6164-6172.
  • 8Dignass AU,Podolsky DK.Cytokine modulation of intestinal epithelial cell restitution:central role of transforming growth factor beta[J].Gastroenterology,1993,105(5):1323-1332.
  • 9Abreu MT,Arnold ET,Thomas LS,et al.TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells[J].J Biol Chem,2002,277(23):20431-20437.
  • 10Salmenpera P,Hamalainen S,Hukkanen M,et al.Interferon-gamma induces C/EBP beta expression and activity through MEK/ERK and p38 in T84 colon epithelial cells[J].Am J Physiol Cell Physiol,2003,284(5):C1133-C1139.

同被引文献42

  • 1雷娜,孔鹏飞,陈思敏,唐学贵.槐花散合桃花汤加减对溃疡性结肠炎活动期寒热错杂证免疫炎症的调节作用[J].中国实验方剂学杂志,2020,0(7):86-91. 被引量：32
  • 2孙少川,郑春宁,曲飞,刘国勤,姜永胜.重组人生长激素对大鼠肠缺血再灌注后肠壁组织T淋巴细胞亚群和浆细胞的影响[J].中华实验外科杂志,2005,22(4):447-449. 被引量：5
  • 3范骏,谢勇（审校者）.肠道黏膜免疫[J].国际免疫学杂志,2006,29(2):111-115. 被引量：33
  • 4Hassoun HT, Kone BV, Mercer DW, et aI. Post-injury multi- ple organ failure: the role of the gut. Shock ,2001,15(1) :1-10.
  • 5Gostishchev VK, Afanas'ev AN, Kruglianskil IuM, et al. Bacterial translocation under the conditions of acute bowel obstruction. Vestn Ross Akad Med Nauk,2006, (9-10):34-38.
  • 6Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol, 2003,3 (4) : 331-341.
  • 7Brandtzaeg P, Halstensen TS, Kett K, et al. Immunobiology and immunopathology of human gut mueosa: humoral immuni- ty and intraepithelial lymphocytes. Gastroenterology, 1989,97 (6) : 1562-1584.
  • 8Schenk M, Mueller C. The mucosal immune system at the gas- trointestinal barrier. Best Praet Res Clin Gastroenterol,2008, 22(3) :391-409.
  • 9Slijper N, Sukhotnik I, Chemodanov E, et al. Effect of simv- astatin on intestinal recovery following gut ischemia-reperfusion injury in a rat. Pediatr Surg Int,2010 ,26(1):105-110.
  • 10Yusifzade K, Akin M, Isikgonul I, etal. The protective role of anandamide in mesenteric ischemia reperfusion injury in guinea pig. Bratisl Lek Listy,2009,110(7) :379-384.

引证文献2

二级引证文献28

国外医学（免疫学分册）
2005年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部