摘要
目的研究慢性肺心病患者急性期和恢复期凝血、纤溶和抗凝指标的变化。方法对62例慢性肺心病患者于入院后1d(急性期)及出院前1d(缓解期),以及60例健康体检者(正常对照组)分别抽血检测APTT、PT、FVIIIC、抗凝血酶活性(ATC)以及D-二聚体等指标。结果慢性肺心病组缓解期PT与正常对照组比较,差异无显著性意义,但其他指标差异均存在显著性意义。慢性肺心病组急性期与缓解期比较,急性期APTT、PT显著缩短(P<0.05),FVIIIC显著升高(P<0.05),ATC显著减低(P<0.05),D-二聚体显著增高(P<0.01)。结论慢性肺心病患者存在凝血、纤溶和抗凝系统的紊乱,表现为高凝血活性、低抗凝活性和高纤溶活性,急性期比缓解期更严重。
Objective To investigate the change of the blood coagulation, fibrinolysis and anti-coagulation system indexes in patients with chronic pulmonary heart disease during acute stage and recovery stage. Methods APTT, PT, plasma antithrombin activity（AT： C） and D-dimer concentration were measured in 62 patients with chronic pulmonary heart disease during acute stage and recovery stage , and 60 healthy controls, respectively. Results Comparing with healthy controls, all of the measured indexes in patients were significantly changed except PT in patients in recovery stage. In the patients during acute stage, APTT and PT were significantly shortened than those in recovery stage（P 〈 0.05）, and FⅧ ： C, D-dimer were significantly inereased（P 〈 0.05 andP 〈 0.01 respectively）, whereas AT： C were significantly decreased （P 〈 0.05） . Conclusion The results revealed that abnormality of the blood coagulation, fibrinolysis and anti-coagulation system were existed in the patients with chronic pulmonary heart disease. The patients showed high coagulation and fibribolysis activity, and low anti-coagulation activity. This situation was more serious in patients during acute stage than those in recovery stage.
出处
《全科医学临床与教育》
2005年第4期218-219,224,共3页
Clinical Education of General Practice
