摘要
过氧化物酶体增长因子活化受体(peroxisome proliferator-activated receptor,PPAR)属于核激素受体超家族,目前已鉴别出3种PPAR亚型(PPARα、PPARγ和PPARδ),其中PPARγ与肿瘤的关系已日益引起人们关注。现有资料表明,PPARγ激动剂通过抑制增殖、诱导细胞凋亡及分化、抑制血管形成和降低肿瘤侵袭能力等不同机制发挥抗肿瘤作用,有望成为肿瘤化疗的一个新途径。
Peroxisome proliferatovactivated receptor （PPAR） belongs to the superfamily of nuclear hormone receptor, Three PPAR subtypes have been identified to date （PPARα, PPARγ and PPARδ）and the relationship between PPARγ and tumor has drawn great attention. Current data showed that PPARy agonists exert their antineoplastic effect through inhibiting cell growth and angiogenesis,inducing cell apoptosis and differentiation,and reducing tumor invasive ability. PPARγ agonists may be a promising tool for cancer chemotherapy.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2005年第11期1290-1292,共3页
Academic Journal of Second Military Medical University
基金
国家重大基础研究发展规划("973"计划)(2002CB523100)
