摘要
目的探讨羟基喜树碱(HCPT)联合草酸铂(L-OHP)、四氢叶酸(CF)、5-Fu方案治疗晚期消化道肿瘤的近期疗效和毒副反应.方法 43例晚期消化道肿瘤患者应用HCPT加L-OHP、CF、5-Fu联合方案化疗(OLF-H方案).L-OHP 130 mg/m2,滴注2 h,d1;HCPT 6 mg/m2,连续滴注6 h,d1～4;每天1次,首次于L-OHP后给药;CF 150 mg/m2,d2～6;5-Fu 500 mg/m2,d2～6;28 d为一个周期.结果完全缓解(CR)4例,部分缓解(PR)18例,总有效率为51.2%(22/43).主要不良反应为骨髓抑制和消化道反应.白细胞减少发生率为51.2%,Ⅲ～Ⅳ度为9.3%(4/43).消化道不良反应主要为恶心、呕吐,发生率为62.8%,但Ⅲ～Ⅳ度为18.6%(8/43).结论羟基喜树碱联合草酸铂、四氢叶酸、5-Fu方案(OLF-H方案),对晚期消化道肿瘤有较好疗效,不良反应可以耐受.
Objective To study the therapeutic efficacy and toxicity of combination of hydroxycamptothecine, oxaliplatin, 5-Fu and leucovorin（CF） on patients with advanced digestive tract carcinomas. Methods Forty-three patients with advanced digestive tract carcinomas received combined chemotherapy of hydroxycamptotheine 6 mg/m^2, dl-4; oxaliplatin 130 mg/m^2, dl ; CF 150 mg/m^2, and 5-Fu 500 mg/m^2 on days 2-6,28 days for an cycle. Results Four case achieved CR and eighteen achieved PR in 43 patients, and the overall response rate was 46.5% .The main toxicity was leukopenia （51.2%） ,and the digestive response rate was 62.8% .But the toxicity of grade Ⅲ～Ⅳ were only 9.3% and 18.6% respectively. Conclusion Combination of hydroxycamptothecine, oxaliplatin, leucovorin and 5-Fu are well tolerated and effective in the treatment of advanced digestive tract carcinomas.
出处
《中国肿瘤临床与康复》
2005年第5期446-448,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
