摘要
目的探讨尿毒症患者血清中新喋呤(NP)和生物喋呤(BP)的浓度变化及其临床意义。方法采用反相高效液相色谱-荧光检测(RP-HPLC-FD)的方法,分别测定正常对照组、尿毒症组透析前后血清中的NP、BP浓度,并进行比较。结果尿毒症组血清中的NP、BP浓度和NP/BP比值均显著高于正常组(P<0.01),透析后血清中的NP、BP浓度显著低于透析前血清中NP、BP浓度(P<0.01,P<0.05),而NP/BP比值差异无显著性(P>0.05)。结论在尿毒症患者中,血清中的NP、BP浓度可作为炎性介质激活的灵敏指标,同时可作为判断肾功能好坏的标志物。
Objective To study the changes of serum levels of neopterin（NP） and biopterin（BP） in uremia patient and its clinical significance. Methods Serum NP and BP were determined in uremia patients before and after dialysis and in control group by RP-HPLC-FD method. Results The levels of serum NP, BP and the NP/BP ratio in uremia were significantly higher than that in control group （ P 〈 0.01 ）. Serum NP and BP in uremia patients increased more significantly before dialysis than that after dialysis. But there was no difference of the ratio NP/BP before dialysis and after dialysis （P 〉 0.05）. Conclusions Serum NP and BP in uremia patients were sensitive markers of inflammation medium activating and could be used to assess the dysfunction of kidney.
出处
《检验医学》
CAS
北大核心
2005年第6期505-507,共3页
Laboratory Medicine
