摘要
本文对1029例系统性红斑狼疮患者,分单纯中药、单纯西药、中西医结合治疗等三组进行了临床研究。治疗结果:中西医结合治疗组总有效率90.1％、显效率40.6％,高于其它两组。且对其中621例进行平均5.5年的追踪观察结果,结合组远期疗效存活率90.2％、缓解率34.9％,均明显高于其它两组,有非常显著的统计学差异,存活生存质量也显著优于其它两组。治疗后结合组激素维持量明显低于西药组而血浆皮质醇测定值基本相同、T淋巴细胞亚群测定值显著改善,提示中药有调节内分泌和免疫机能的作用。用狼疮冲剂治疗临床及病理改变类似人类SLE的狼疮鼠,药理药效学动物实验结果表明:中药可明显降低狼疮鼠血清ANA的形成及肾组织IgG、C_3的沉积,减少蛋白尿,其疗效接近或优于强的松。临床及实验研究结果证实,中西医结合疗法能有效地调节机体免疫机能,延长缓解期,提高疗效。
1029 cases of SLE were divided into 3 groups and treated with TCM.WMand TCM - WM respectively.according to the syndrome differentiation of TCM. The treatment were selected into 4 types-, noxious heat damage of vitality and blood , dificiency of the spleen and kidney, deficiency of the spleen, depression of liver energy. Results showed that.the total effective rate including the remission rate was 40. 6% .the late results including of the remis- sioii ratt-. survival rate in TCM - WMgroup whit-h were much higher than those of other 2 groups (I->< 0. 05). After therapy-the average dosage of corticosteroids in the TCM - WM group more decreased and a more decreased figure of in the corticosteroids in the 1 CM -WM group was fornd(P<0. 01). The Side -effect induced by the corticosteroids in the TCM - WM group was less than the WM group. All the differences were statistically significant. We have worked out the 'LASGCHVANG mixture 'and 'LANGCHl.'ANG granule 'to treat dificiency of vital energy in the spleen and kidney of SLE and the result was satisfactory.
The animal pharmacological experiment results showed that ' LANGCHUANG granule 'results could inhibit the form of ANA in serum, decrease the Kidney deposit of IgG and C,.decrese proteinuria of male BXSB mice in treating male BXSB mice.
出处
《中国中医药科技》
CAS
1996年第4期11-15,共5页
Chinese Journal of Traditional Medical Science and Technology
