摘要
目的探讨47例药物性肝炎患者的病因和临床特点,以提高对该病的认识。方法采用回顾性分析法对47例药物性肝炎住院患者的用药史、临床表现、肝功能检查、病原学标志以及治疗转归做出综合分析。结果引起肝病的相关药物中抗生素类占23.4%(11/47),中药及解热镇痛药各占21.3%(10/47)、抗肿瘤药占10.6%(5/47)、抗结核药及H2受体拮抗剂各占8.5%(4/47)、其他占6.4%(3/47)。临床表现为急性肝炎44例,慢性肝炎3例(主要有乏力、纳差、黄疸和转氨酶升高)。经停药并给予保肝治疗,45例预后良好,1例发展至肝硬化,1例因重症肝炎而死亡。结论应重视药物性肝炎的预防、诊断和治疗。
Objective To expand the knowledge of drug-induced liver disease by analyzing the etiology and clinical features of 47 patients with drug-induced hver disease. Methods 47 cases with drug-induced liver damage admitted to our hospital from 1995 to 2004. They were reviewed with respect to their drug history, clinical symptom and signs, liver function test, serum viral markers and therapeutic effect. Results The drugs involved were antibiotics in 23.4%, analgesics and herbal medicine in 21.3 %, respectively, anti-tumor agents in 10.6%, anti-tuberculous agents and H2 -receptor antagonist in 8.5 % , respectively. There were 44 patients with acute and 3 with chronic drug-induced liver disease. The dominating clinical manifestations were fatigue, loss of appetite, jaundice and elevated transaminase.45 patients （93.6%） were recovered with good prognosis. Conclusion Prevention and diagnosis of drug-induced liver disease is of importance in clinical practice.
出处
《实用肝脏病杂志》
CAS
2005年第6期334-336,共3页
Journal of Practical Hepatology
关键词
药物性肝炎
临床特点
Drug-induced liver disease
Clinical feature
