摘要
目的研究2型糖尿病患者颈动脉内膜-中层厚度(IMT)的改变,探讨其与各种相关危险因素的关系。方法141例2型糖尿病患者分为合并高血压组(n=70)和非高血压组(n=71),采用高分辨率彩色多普勒超声显像仪测量颈动脉IMT,同时测定相关危险因素并进行统计学分析。以71例老年健康体检者作为正常对照组。结果糖尿病非高血压组和合并高血压组IMT、血总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、餐后血糖(PBG)和胰岛素敏感性(ISI)均显著高于正常对照组。糖尿病合并高血压组IMT、TC、LDL-C、FPG显著高于非高血压组。结论糖尿病和高血压同时存在加速动脉粥样硬化的进程。IMT测量对2型糖尿病心脑血管疾病高危患者,具有早期发现和筛选作用。
Objective To investigate carotid artery intima-media thickness（IMT） and relation of risk factors in patients with type 2 diabetes mellitus （DM）. Methods The IMT of carotid artery were assessed by high resolution Doppler uhrasonography in 141 patients with type 2 DM and 71 healthy controls, and the relation of risk factors was analyzed by multiple stepwise regression. Results The IMT, TC, LDL-C, FPG, PBG and ISI were obviously higher in diabetes and diabetes combined with hypertension than in the controls. The IMT, TC, LDL-C and PBG were obviously higher in diabetes combined with hypertension than that in diabetes without hypertension. Conclusion Diabetes mellitus and hypertension may accelerate atherosclerosis. Measure must of IMT is a way to detect early in patients of high risk factors with heart diseases.
出处
《上海第二医科大学学报》
CSCD
北大核心
2005年第11期1151-1153,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
2型糖尿病
高血压
颈动脉
内膜-中层厚度
type 2 diabetes mellitus
hypertension
carotid artery
intima-media thickness
