摘要
【目的】研究幽门螺杆菌(HP)与胃黏膜白细胞介素(IL-8)和粒细胞集落刺激因子(G-CSF)相关胃炎的关系。【方法】采用酶联免疫吸附试验法测定47例HP阳性和27例HP阴性的慢性胃炎和消化性溃疡患者的胃黏膜IL-8、G-CSF的含量,其中HP阳性27例治疗4周后复查。【结果】HP感染时胃黏膜IL-8、G-CSF含量较HP阴性者高,其含量增高与炎症活动度,严重程度及溃疡有相关性。HP清除后胃黏膜IL-8、G-CSF含量降低(P<0.01)。【结论】HP感染可以诱导胃黏膜炎症细胞合成和释放IL-8及G-CSF,它们可能在HP相关性胃、十二指肠疾病的发病过程中发挥关键作用,是引起炎症以及进一步病理损害的重要途径。
[Objective]To study the correlation of Helicobacter pylori（HP） and gastritis with Interleukin-8 （IL-8） and Granulocyte colony-stimulating factor（G-CSF）. [Methods]Forty-seven HP positive and 27 HP negative patients with chronic gastritis and gastric ulcers were enrolled in this study. Their gastric IL-8 and G-CSF were measured with ELISA,and the two targets of 27 HP positive patients were measured after treatment of 4 weeks. [Results]The contents of gastric IL-8 and G-CSF in HP positive patients were higher than those of HP negative patients. Their contents were not correlative to chronic gastritis and gastric ulcers. The contents of gastric IL-8 and G-CSF were decreased after HP elimination,and the difference before and after HP elimination was significant（ P 〈0.01）. [Conclusion]HP infection can induce inflammatory cells to synthesize or secrete IL-8 and G-CSF,which may play an important role in the pathogenesis of HP related gastrointestinal disease, and they are important pathway to induce inflammation and progressive pathological damage.
出处
《医学临床研究》
CAS
2005年第12期1665-1667,共3页
Journal of Clinical Research
关键词
螺杆菌
幽门
螺杆菌感染
白细胞介素8
粒细胞集落刺激因子
胃粘膜
helcobacter pylori
helicobacter infections
interleukin-8
granulocyte colony-stimulating factor
gastric mucosa
