摘要
目的观察缺氧缺血性脑病(HIE)新生儿脑血流动力学的动态变化。方法经颅多普勒超声动态探测75例HIE患儿和50例健康新生儿的大脑中动脉血流速度和脉动指数(PI)值,并结合临床及预后进行分析。结果健康新生儿血流速度逐渐加快,PI值2～5d轻度降低。HIE患儿12h和1d时流速明显降低、PI值显著增高(P<0.05),2～5d时流速明显增快、PI值显著降低(P<0.05),其中血流速度的降低和Apgar评分呈正相关,流速增快和Apgar评分呈负相关。预后不良患儿血流速度的变化更加明显(P<0.05),且发生时间较早。结论脑血流动力学改变可以反映HIE的病理机制和严重程度,并有预后预测的价值。
Objective To observe the dynamic change of cerebral blood flow of newborns with hypoxic - ischemic encephalopathy （HIE）. Methods Cerebral blood flow of middle cerebral artery and pulsatility index（PI） on 75 newborns with HIE and 50 normal infants were examined with transcranial doppler sonography at different time points, and the relations between cerebral blood flow and clinic indexes were analyzed. Results The blood velocity of normal infants increased gradually, and PI decreased from 2 to 5 days. The velocities were lower than that of normal infants,and PI was higher at 12th hour and 1st day, but during 2 - 5 days,the velocities got higher and PI got lower, in which the decrease of velocities correlated positively with Apgar scores and the increase of velocities were negatively correlative to Apgar scores. Compared with the neonates who had poor prognosis retrospectively with those had good prognosis, the velocity changes were found to be more significant. Conclusion The change of cerebral blood flow can show the pathophysiology of HIE and prognosticate the prognosis of neonates with HIE.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第12期1219-1221,共3页
Journal of Applied Clinical Pediatrics
关键词
婴儿
新生
缺氧缺血
脑
脑血流
血流动力学
infant, newborn
hypoxic - ischemic encephalopathy
cerebral blood flow
hemodynamic
