摘要
目的探讨子宫交界性平滑肌肿瘤与子宫平滑肌瘤和平滑肌肉瘤在病程及临床表现方面的差异。方法回顾性分析131例富于细胞或生长活跃的平滑肌瘤患者的病理及临床资料。重新阅读病理切片,必要时重新取材,并对患者进行随访。结果子宫交界性平滑肌瘤预后良好,5年生存率达100%。但有19.1%(24/131)有远期复发,其中8例有多次复发,复发患者5年生存率为91.7%。分析复发特别是多次复发患者的病理特征,发现其有丝分裂及细胞异型性明显加重,即出现去分化的改变,多次复发者5年生存率仅为75.0%。结论子宫交界性平滑肌瘤的病理及临床行为在某些方面与子宫肌瘤或子宫平滑肌肉瘤存在差异,临床处理时应强调长期随访的重要性。
Objective To investigate whether the border-line uterine smooth-muscle tumor is different from leiomyoma or leiomyosarcoma in history and clinical manifestations, Methods The medical records of 131 surgically treated patients suffering from the so-called cellular leiomyoma or mitotically active leiomyoma of the uterus treated from 1984 to 2002 were retrospectively reviewed. All pathological sections of these patients were reviewed by a senior pathologist. Chi-square test and Kaplan-Meier life table were used for statistical analysis. Results The overall 5-year survival rate of patients with the border-line uterine smooth-muscle tumors was 100% , however, 19. 1% （24/131） of whom developed a late recurrence and 8 patients had repeated recurrences with a more shortened course and aggressive potential changes of mitosis and cellular atypia. The overall 5-year survival rate the patients with recurrence was 91. 7% , but only 75.0% for those with repeated recurrences. Conclusion Patients with border-line uterine smooth-muscle tumor do possess some difference in nature from the leiomyoma or leimyosareoma. Long-term follow-up is very important for these patients after surgery.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2005年第11期698-700,共3页
Chinese Journal of Oncology
关键词
子宫肿瘤
平滑肌瘤
病理学
治疗
Uterine neoplasm
Leiomyoma
Pathology.
Treatment
