摘要
目的:制备西替利嗪凝胶剂,并建立质量控制方法。方法:以卡波姆940为基质制备凝胶,采用紫外分光光度法测定西替利嗪含量,并考察其稳定性。结果:西替利嗪线性范围为6～16mg·L-1(r=0.9967),平均回收率为98.23%,RSD为0.69%(n=5),凝胶稳定性良好。结论:该凝胶制备工艺可行,性质稳定。
OBJECTVIE To prepare cetirizine gel and establish a quality control method for the gel. METHODS Carbopol 940 was used the gel base, the content of cetirizine was determined with UV-spectrophotometry and the stability test was performed. RESULTS There was a good linearity of calibration curve of cetirizine in range of 6-16 mg·L^-1 ,r= 0. 996 7,the average recovery was 98. 23%. RSD was 0. 69% （n= 5） The gel was stable. CONCLUSION The design of the gel formulation is reasonable. The gel can be prepared feasibly and is stable in quality, convenient in use.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2005年第8期740-741,共2页
Chinese Journal of Hospital Pharmacy
关键词
西替利嗪
凝胶剂
制备
质量评价
cetirizine
gel
preparation
quality assessment
