摘要
目的探讨胃肠道间质瘤(GIST)的临床病理、免疫组化特征及其诊断和鉴别诊断。方法对67例胃肠道间质瘤进行临床病理分析,并观察其免疫组化标记物CD117、CD34、SMA、S-100、Nestin的表达。结果胃肠道间质瘤形态结构多样,基本形态以梭形细胞及上皮细胞样为主,呈编织状、栅栏状排列,免疫组化67例中62例CD117阳性、52例CD34阳性、63例Nestin阳性、部分病例有SMA、Desmin、S-100的表达,多为局灶性弱阳性。结论胃肠道间质瘤是以上皮细胞样及梭形细胞为主的胃肠道间叶源性肿瘤,CD117、CD34、Nestin的表达是确诊该病的依据。
Objective To discuss pathological and immunohistochemical characteristics and their diagnosis. Methods Tumor tissues from 67 cases with GIST were analyzed. Expressions of CD117, CD34, SMA, DES, S-100 and Nestin were detected by immunohistochemistry. Results GIST is a neoplasm with variable cells and structures. Most of the cells were spindle or epithelia. The histological spectrum included mesh and palisade pattern. Immunohistoehemically, 62 cases were positive for CD117, 52 cases expressed CD34, 63 cases expressed Nestin. Part of these cases showed SMA, DES, S-100 with local and mild positive. Conclusion GIST is a neoplasm of gastrointestinal mesenchymal tumors which consists of spindle and epithelia cells. The expression of the CD117, CD34 and Nestin can be used to identify GIST.
出处
《实用临床医药杂志》
CAS
2005年第11期70-74,共5页
Journal of Clinical Medicine in Practice
