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动脉粥样硬化进程中脂联素的研究进展

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摘要 脂联素(adiponectin)是由脂肪细胞分泌的一种特殊血浆蛋白,正常人体中血浆脂联素含量丰富。体外研究发现脂联素抑制各种细胞黏附分子的表达;细胞培养证实脂联素可抑制血管细胞及平滑肌的增殖,并抑制单核-巨噬细胞的迁移及向泡沫细胞的转化;动物实验发现脂联素基因缺陷小鼠动脉内膜明显增厚;临床研究发现肥胖、糖尿病、代谢综合征、冠心病患者血浆脂联素水平明显下降。种种迹象表明脂联素具有抗动脉粥样硬化的作用。
作者 吴玥婷 陈鲁原
机构地区 广东省人民医院广东省心血管病研究所
出处 《岭南心血管病杂志》 2005年第6期444-446,共3页 South China Journal of Cardiovascular Diseases
关键词 脂联素 动脉粥样硬化 抗炎 抗动脉粥样硬化
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献25

  • 1Trayhurn P,Beattie JH.Physiological role of adipose tissue:white adipose tissue as an endocrine and secretory organ [J].Proc Nutr Soc,2001,60(3):329-339.
  • 2Gong D,Yang R,Munir KM,et al.New progress in adipocytokine research [J].Curr Opin Endocrinol Diabetes,2003,10(2):115-121.
  • 3Shimada K,Miyazaki T,Daida H.Adiponectin and atherosclerotic disease [ J ].Clinica Chimica Acta,2004,344(1):1-12.
  • 4Yamauchi T,Kamon J,Waki H,et al.Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis [J].J Biol Chem,2003,278 (4):2461-2468.
  • 5Arita Y,Kihara S,Ouchi N,et al.Paradoxical decrease of an adipocyte specific protein,adiponectin,in obesity [J].Biochem Biophys Res Commun,1999,257(1):79-83.
  • 6Saltiel AR.A hypothetical model for the secretion and action of adiponectin [ J ].Nat Med,2001,7 (8):887-888.
  • 7Ouchi N,Kihara S,Funahashi T,et al.Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue [J].Circulation,2003,107 (5):671-674.
  • 8Bernstein EL,Koutkia P,Ljungquist K,et al.Acute regulation of adiponectin by free fatty acids [J ].Metabolism,2004,53 (6):790-792.
  • 9Gavrila A,Chan JL,Yiannakouris N,et al.Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans:cross-sectional and interventional studies[J].J Clin Endocrinol Metab,2003,88(10):4823-4831.
  • 10Kawanami D,Maemura K,Takeda N,et al.Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells:a new insight into adipocytokine-endothelial cell interactions [J].Biochem Biophys Res Commun,2004,314(2):415-419.

二级参考文献34

  • 1刘军,陈影,刘芳,姚庆姑,许火根,澎名淑,郭瑜琳,陈钦达.2型糖尿病家系非糖尿病一级亲属脂联素水平与胰岛素抵抗和动脉粥样硬化相关性研究[J].中华内分泌代谢杂志,2004,20(3):215-216. 被引量：30
  • 2Okamoto Y, Arita Y, Nishida M, et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res, 2000,32:47-50.
  • 3Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway. Circulation, 2000,102:1296-1301.
  • 4Yokota T, Oritani K, Takahashi I, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood, 2000,96:1723-1732.
  • 5Matsuda M, Shimomura I, Sata M, et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem, 2002,277:37487-37491.
  • 6Kubota N, Terauchi Y, Yamauchi T, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem, 2002,277:25863-25866.
  • 7Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.Biochem Biophys Res Commun, 1999,257:79-83.
  • 8Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol, 2000,20:1595-1599.
  • 9Kumada M, Kihara S, Sumitsuji S, et al. Association of hypoadi-ponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol, 2003,23:85-89.
  • 10Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol, 1983,51:606.

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岭南心血管病杂志
2005年 第6期

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