摘要
目的分析慢性苯中毒导致的再生障碍性贫血患者的治疗原则。方法16例苯导致的再障患者均于发病后迅速脱离苯及其他有毒物质的接触并住院治疗,1例联合应用抗淋巴细胞球蛋白和环胞素A,9例单用环胞素A,其余6例未采用免疫抑制治疗。结果16例患者中,除1例因经济原因放弃治疗并死亡外,其余15例均基本治愈,而且免疫抑制剂的应用未超过2个月,随访12个月无复发。结论对部分因苯中毒所致的再障患者,免疫异常是由造血干细胞受损导致,只要治疗及时得当,即使无免疫抑制剂的应用,也可以获得满意的疗效。
Objective To analyze the treatment of aplastic anemia secondary to chronic benzene poisoning. Methods 16 patients with secondary aplastic anemia resulting from benzene poisoning promptly discontacted with benzene and admitted to hospital after onset. 1 patients was treated with antilymphocyte globulin and cyclosporine A, 9 patients accepted cyclosporine A alone and the other 6 were treated without immunosuppressive drugs. Results 15 were cured and didn＇ t relapse with a follow-up of 12 months except 1 discontinued treatment and died. The application of immunosuppressive drugs was not longer than 2 months in these cured patients. Conclusion In some patients with secondary aplastic anemia on accout of benzene intoxicity, immunologic aberrations results from the destruction of hematopoietic stem cells and most of them can obtain satisfying prognosis on proper therapy even without immunosuppressive drugs.
出处
《临床内科杂志》
CAS
2006年第1期41-43,共3页
Journal of Clinical Internal Medicine
关键词
苯
贫血
再生障碍性
治疗
Benzene
Anemia, aplastic
Treatment
