摘要
目的:探讨美托洛尔对糖尿病模型大鼠胰岛素敏感性的影响。方法:高脂饲料喂养SD大鼠予链脲菌素(25mg.kg-1,ip)诱发糖尿病模型,给予不同剂量的美托洛尔(按3,10,30mg.kg-1.d-1分3组),观察实验前、实验4,8周后大鼠血糖、血脂(TC、TG)、糖化血红蛋白(HbA1c)、胰岛素敏感性的变化。结果:不同剂量的美托洛尔对糖尿病大鼠血糖、血脂、HbA1c、胰岛素敏感性均无显著影响。结论:美托洛尔在30mg.kg-1范围内不影响糖尿病模型大鼠血糖、血脂、胰岛素敏感性。
OBJECTIVE To investigate the effect of metoprolol on the sensitivity of insulin in Steptozocin-duduced （SD） rats with diabetes . METHODS SD rats were feed with diets enriched with fat and cholesterol, diabetic rats model were developed by intraperitoneal injection with 25 mg·kg^-1 streptozotocin （STZ） . Three subgroups were divided randomly and different dose（ 3,10,30mg·kg^-1· d^-1） metoprolol were given according to body weight. 5 rats were killed randomly from every group at the beginning of experiment and after treated for 4 weeks and 8 weeks respectively, blood glucose, fast insulin, serum cholesterol, triglyceride, glycated hemoglobin were determined. RESULTS From the experiment, we found：there was no effect on blood glucose, insulin sensitivity, blood cholesterol, triglyceride, and glycated hemoglobin in every metoprolol groups. CONCLUSION Within the dosage range of 30 mg· kg^-1, metoprolol not only had no effect on blood glucose, insulin sensitivity, blood total cholesterol, low density cholesterol, triglyceride.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2006年第1期22-24,共3页
Chinese Journal of Hospital Pharmacy
