摘要
目的了解10多年来中国乙型肝炎(乙肝)疫苗预防接种效果.方法利用2002年'中国居民营养与健康状况调查'保留的血清,以美国Abbott公司乙肝酶联免疫吸附试验(EILSA)试剂为标准,选择中国乙肝ELISA检测试剂开展乙肝病毒感染标志的血清学检测,并用固相放射免疫(SPRIA)方法校对检测结果.结果①乙肝疫苗接种人群乙肝病毒表面抗原(HBsAg)阳性率、乙肝病毒(HBV)感染流行率,经调整后分别为5.28%、54.44%,3～12岁儿童分别为3.63%、26.88%.②未接种乙肝疫苗人群HBsAg阳性率、HBV感染流行率,经调整后分别为9.51%、64.63%,3～12岁儿童分别为11.19%、47.03%.③接种乙肝疫苗人群城市、农村HBsAg阳性率分别为2.55%、7.10%,未接种乙肝疫苗人群分别为7.24%、10.12%;3～12岁接种乙肝疫苗儿童城市、农村HBsAg阳性率分别为1.96%、6.65%,未接种儿童分别为2.39%、10.84%.结论中国乙肝疫苗预防接种效果好;同时反映了农村乙肝疫苗的预防接种是中国乙肝防制的重中之重.
Objective To understand and measure the effect of 10-years immunization activities,we decided to conduct seroepidemiological study using the remaining blood sampling of Nationwide Survey of Nutrition and Health in Chinese residents,which was conducted in 2002. Methods HBsAg, anti-HBs, and anti-HBc in blood samples were detected using ELISA reagents and revised by SPRIA and Abbott ELISA reagents. Results （1）Among the vaccinated population,the adjusted prevalence rate of HBsAg is 5.28 % , and the rate of HBV infection is 54.44 %. For the vaccinated children from 3 - 12 years old, the rate is 3.63% and 26.88%, respectively. （2）Among the unvaccinatted population, the rate of HBsAg is 9.51% and the rate of HBV infection is 64.63%. For the children of 3 - 12 years old, the rate is 11.19% and 47.03% respectively. （3）Among the vaccinatted population, the rate of HBsAg is 2.55 % in urban area and 7.10% in rural area. For the unvaccinatted population, the rate is 7.24% and 10.12%, respectively. Among the vaccinatted children from 3 - 12 years old, the rate of HBsAg is 1.96 % in urban area and 6.65% in rural area. For the unvaccinated children, the rate is 2.39% and 10.84%, respectively. Conclusion The results showed that the effect of 10-years immunization activities is prominent and suggested that it was the most important to improve the coverage of hepatitis B vaccine in the rural children for prevention and control campaign of hepatitis B.
出处
《中国计划免疫》
2005年第6期465-469,共5页
Chinese Journal of Vaccines and Immunization
